Metabolomic analyses of Drosophila models for human metabolic disorders
Event details
| Date | 11.09.2012 |
| Hour | 16:00 › 17:00 |
| Speaker |
Prof. Toshiro Aigaki Department of Biological Sciences, Tokyo Metropolitan University |
| Location |
AI1153
|
| Category | Conferences - Seminars |
The fruit fly, Drosophila melanogaster shares many genes with humans: approximately 75% of diseases-related genes in humans have orthologs in the fly, and it has been used as a model system to study molecular and genetic bases of human diseases. However, relatively little has been studied for mutations in genes involved in energy metabolism, whose defects may cause metabolic disorders, such as diabetes, heart disease, fatty liver, and several cancers. To facilitate the understanding of molecular bases of these diseases, we are currently generating and analyzing loss-of-function mutations in metabolic genes in Drosophila. We search for such mutations among the collection of transposon insertion lines, or generate knockout mutant by gene-targeting. To characterize the mutants, we used liquid chromatography mass spectrometry (LC-MS), which is a powerful tool for metabolomics. I will present the phenotypic and metabolomic properties of Drosophila mutants, which showed the symptoms of lipoic acid synthase (LIAS) deficiency and mitochondrial trifunctional protein (MTP) deficiency in humans.
Practical information
- General public
- Free
Organizer
- Prof. Bruno Lemaitre