Molecular interplay that controls glucose and glycogen metabolism in muscle
Event details
| Date | 07.03.2011 |
| Hour | 11:30 |
| Speaker | Kr Kei Sakamoto, MRC, UK |
| Location | |
| Category | Conferences - Seminars |
The aim of my research is to elucidate the molecular mechanisms that control glucose and energy homeostasis and ultimately identify novel drug targets aimed at treating metabolic disorders such as type 2 diabetes. Many of the key metabolic enzymes are strictly and co-ordinately controlled through interplay between allosteric and covalent (e.g. phosphorylation) regulations by various extracellular and intracellular factors such as hormones and energy stress. Elucidating the molecular control and physiological role of such interplay is critical to understand the complex metabolic processes in the body. To achieve this, we have been studying the regulatory mechanisms of key metabolic/signalling enzymes and generating unique genetic models. This approach enables us to establish primary mechanism by which insulin and exercise control muscle glucose uptake and glycogen storage in vivo.
Links
Practical information
- General public
- Free
Contact
- IBI Sandwich Seminar Series - organized jointly with the Lausanne Integrative Metabolism & Nutrition Alliance (LIMNA)