Molecular Mechanisms Involved in Neurodegenerative Diseases: a Genetic, Environmental and Biological Factors Study
Event details
| Date | 26.03.2014 |
| Hour | 14:00 › 15:00 |
| Speaker | Carl Julien, Ph.D., Université de Montréal, Québec (CA) |
| Location | |
| Category | Conferences - Seminars |
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)
Abstract:
For many neurodegenerative diseases, environmental and biological factors may interfere with genetic susceptibilities and lead or not to disease manifestation. Here, we found changes in fatty acid profiles from human brain samples of Alzheimer’s disease (AD) and Parkinson’s disease (PD) patients and a decrease of SIRT1 levels in AD brain. We also observed in mouse models of type 1 and type 2 diabetes and in mice anesthetized an aggravation of tau and Aβ pathologies, the two hallmarks of AD. We also found changes in synaptic markers and in brain fatty acid profiles in mice fed a high-fat diet. Moreover, using genetic models in C. elegans and mouse, we observed involvement of endoplasmic reticulum (ER) stress pathway, the DNA-binding proteins TDP-43 and FUS, and the secreted growth factor progranulin in polyglutamine (polyQ) toxicity found in Huntington’s disease (HD). We also investigated drugs targeting these pathways to identify disease modifiers.
Bio:
Dr. Julien is a Postdoctoral Fellow in the Labs of Drs. Alex Parker and Pierre Drapeau, Pathology and Cellular Biology, Department of Neurosciences, Université de Montréal, CRCHUM, Montréal, Québec (CA)
Abstract:
For many neurodegenerative diseases, environmental and biological factors may interfere with genetic susceptibilities and lead or not to disease manifestation. Here, we found changes in fatty acid profiles from human brain samples of Alzheimer’s disease (AD) and Parkinson’s disease (PD) patients and a decrease of SIRT1 levels in AD brain. We also observed in mouse models of type 1 and type 2 diabetes and in mice anesthetized an aggravation of tau and Aβ pathologies, the two hallmarks of AD. We also found changes in synaptic markers and in brain fatty acid profiles in mice fed a high-fat diet. Moreover, using genetic models in C. elegans and mouse, we observed involvement of endoplasmic reticulum (ER) stress pathway, the DNA-binding proteins TDP-43 and FUS, and the secreted growth factor progranulin in polyglutamine (polyQ) toxicity found in Huntington’s disease (HD). We also investigated drugs targeting these pathways to identify disease modifiers.
Bio:
Dr. Julien is a Postdoctoral Fellow in the Labs of Drs. Alex Parker and Pierre Drapeau, Pathology and Cellular Biology, Department of Neurosciences, Université de Montréal, CRCHUM, Montréal, Québec (CA)
Practical information
- Informed public
- Free
Organizer
- Kristina Schoonjans and Johan Auwerx (for the LIMNA Alliance)
Contact
- Johan Auwerx
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