Molecular Modeling of Membrane Embedded Proteins

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Event details

Date 31.05.2013
Hour 18:0019:00
Speaker Thomas Lemmin, Dal Peraro Lab (LBM)
Location
Category Thesis defenses
At present, the experimental determination of high-resolution membrane protein structures is difficult. Combined with in vitro data, molecular modeling is therefore a valuable tool for the structural determination at near-atomistic resolution of this class of proteins. This thesis work shows how molecular simulations and their interplay with available experimental input can help advance the understanding of the mechanism of complex biological systems and processes on a molecular scale. These results, in particular, go well beyond the current understanding of the functioning of two transmembrane proteins relevant for human health: the PhoQ histidine kinase and the Amyloid Precursor Protein. Furthermore, the computational approaches and procedures developed in these projects will hopefully promote novel integrated strategies for investigating biological systems.

Practical information

  • General public
  • Free

Organizer

Contact

  • Institute of Bioengineering (IBI, Dietrich REINHARD)

Tags

molecular modeling transmembrane protein

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