Morphology and Hemodynamics of the Cortical Blood Supply in Humans
Event details
| Date | 11.10.2012 |
| Hour | 16:15 |
| Speaker | Prof. Andreas Linninger |
| Location | |
| Category | Conferences - Seminars |
In the human cortex, there appears to exist a functional coupling between the neurons in the cortical column and its bloodsupply. The dynamic mechanisms in response to neuronal activation triggering increased metabolic oxygen demand and leadingto fast hemodynamic response to meet this demand are not fully understood. There is evidence that the cortical blood supplyduring functional hyperemia is managed by functional blood units (FBU). Each FBU typically consists of a single centraldraining vein with a diameter of about 100um; around it are three to five ring arterioles with approximately 40um in diameter. Wehave generated a computational model of an artificially generated three-dimensional representation of a FBU (see Figure). Themorphometrics of our artificially generated FBU closely matches key anatomical properties of the microvasculature of thehuman cortex including capillary density, distribution, length, and angle spectra. We have evaluated the cerebralmicrocirculation with a morphologically accurate hemodynamic flow model. Results from simulation on the FBU show thedetailed map of the contrast transit times and concentrations, blood pressures, volumetric flow rates, and velocities.
Practical information
- General public
- Free
Organizer
- F. Maréchal
Contact
- F. Maréchal