Multiplexed coding of the cerebellar Purkinje neurons
Event details
| Date | 29.07.2013 |
| Hour | 14:00 › 15:00 |
| Speaker | Sungho Hong |
| Location | |
| Category | Conferences - Seminars |
Multiplexed coding of the cerebellar Purkinje neurons
BBP Sectional Seminar Announcement
Monday, July 29th, 2013,
14h00, Room "BBP Viz Room", QIJ 3rd floor
Speaker:
Sungho Hong
Okinawa Institute of Science and Technology, Japan
Title:
Multiplexed coding of the cerebellar Purkinje neurons
Abstract:
A fundamental problem in neuroscience is uncovering relationships between neurons and the network in which they are embedded, and one of the widely used approaches is to study how correlations in their activities arise and impact the network information processing. In particular, correlations between individual neurons and the overall activity of the network, often probed by local field potential (LFP), have been useful for investigating how single neurons process information in the context of the network.
I will talk about our recent findings that the correlation of the cerebellar Purkinje neuron (PN) firing to the LFP is dynamic and depends on the behavioral context. We analyzed the simultaneous recordings of the cerebellar extracellular potential and eye motion from rhesus monkeys during saccadic eye motion task, and found that the PN spike-LFP correlation is strong and temporally precise at certain transition points in the spiking pattern but otherwise weak. We also found that, while the weak correlation is involved in the slower eye velocity modulation, the strongly correlated spikes are related to the rapid changes in the eye motion such as saccade onsets.
Regarding how the PNs transfer information to the downstream, two opposing views have been debated: in one, synchronization in the PN firings is crucial while, in the other, the population rate code is used and therefore minimizing the correlations is beneficial. Based on our results, I will explain that the PN population code can be multiplexed, i.e., the synchronous and asynchronous spikes can coexist and encode different behavioral informations. I will also discuss what our findings can imply about how the cerebellar cortex communicates with other brain regions for sensorimotor coordination.
Relevant publications:
• Ratté, S., Hong, S., De Schutter, E. and Prescott, S.A. (2013) Impact of neuronal properties on network coding: Roles of spike Initiation dynamics and robust synchrony transfer. Neuron 78, 758-772.
• Hong, S., Ratté, S., Prescott, S.A., and De Schutter, E. (2012a). Single neuron firing properties impact correlation-based population coding. J. Neurosci. 32, 1413–28.
BBP Sectional Seminar Announcement
Monday, July 29th, 2013,
14h00, Room "BBP Viz Room", QIJ 3rd floor
Speaker:
Sungho Hong
Okinawa Institute of Science and Technology, Japan
Title:
Multiplexed coding of the cerebellar Purkinje neurons
Abstract:
A fundamental problem in neuroscience is uncovering relationships between neurons and the network in which they are embedded, and one of the widely used approaches is to study how correlations in their activities arise and impact the network information processing. In particular, correlations between individual neurons and the overall activity of the network, often probed by local field potential (LFP), have been useful for investigating how single neurons process information in the context of the network.
I will talk about our recent findings that the correlation of the cerebellar Purkinje neuron (PN) firing to the LFP is dynamic and depends on the behavioral context. We analyzed the simultaneous recordings of the cerebellar extracellular potential and eye motion from rhesus monkeys during saccadic eye motion task, and found that the PN spike-LFP correlation is strong and temporally precise at certain transition points in the spiking pattern but otherwise weak. We also found that, while the weak correlation is involved in the slower eye velocity modulation, the strongly correlated spikes are related to the rapid changes in the eye motion such as saccade onsets.
Regarding how the PNs transfer information to the downstream, two opposing views have been debated: in one, synchronization in the PN firings is crucial while, in the other, the population rate code is used and therefore minimizing the correlations is beneficial. Based on our results, I will explain that the PN population code can be multiplexed, i.e., the synchronous and asynchronous spikes can coexist and encode different behavioral informations. I will also discuss what our findings can imply about how the cerebellar cortex communicates with other brain regions for sensorimotor coordination.
Relevant publications:
• Ratté, S., Hong, S., De Schutter, E. and Prescott, S.A. (2013) Impact of neuronal properties on network coding: Roles of spike Initiation dynamics and robust synchrony transfer. Neuron 78, 758-772.
• Hong, S., Ratté, S., Prescott, S.A., and De Schutter, E. (2012a). Single neuron firing properties impact correlation-based population coding. J. Neurosci. 32, 1413–28.
Practical information
- General public
- Free
Organizer
- Yihwa Kim