NeuroNA Human Cellular Neuroscience Seminar // Mareike Albert “Gene regulatory mechanisms of neocortex development and evolution”
Supported by the NeuroNA Foundation, the Human Cellular Neuroscience Seminar Series brings the NeuroLéman community together to explore cutting-edge research in brain development, stem cells, organoids, and the mechanisms underlying brain and psychiatric disorders.
Held alternately at EPFL (Lausanne or Campus Biotech) and CHUV/UNIL, our seminars offer both in-person and online participation options, making it easy for everyone to engage with the latest discoveries in neuroscience. Don’t miss this opportunity to expand your knowledge and connect with leading experts in the field!
This time, we are pleased to welcome Mareike Albert who studies gene regulatory mechanisms in brain development, evolution and disease. A recipient of prestigious awards including the Edmond H. Fisher Prize, BIF, CNV, and EMBO fellowships, Mareike employs cortical organoids from various species and from patients with neurodevelopmental disorders to decode the epigenetic regulation in neural stem cells.
Abstract
The neocortex is considered to be the seat of higher cognitive functions in humans. During its evolution, most notably in humans, the neocortex has undergone considerable expansion, which is reflected by an increase in the number of neurons. Epigenetic mechanisms play a pivotal role in orchestrating the behaviour of neural stem cells during development. We are interested in the mechanisms that regulate gene expression in neural stem cells, which have implications for our understanding of neocortex development and evolution, neural stem cell regulation and neurodevelopmental diseases. We employ cortical organoids from different primate species and from patients with neurodevelopmental disorders. I will present our data on the primate-expressed growth factor EPIREGULIN in neocortex evolution and our recent work addressing the role of epigenetic regulation in human cortical development.
Held alternately at EPFL (Lausanne or Campus Biotech) and CHUV/UNIL, our seminars offer both in-person and online participation options, making it easy for everyone to engage with the latest discoveries in neuroscience. Don’t miss this opportunity to expand your knowledge and connect with leading experts in the field!
This time, we are pleased to welcome Mareike Albert who studies gene regulatory mechanisms in brain development, evolution and disease. A recipient of prestigious awards including the Edmond H. Fisher Prize, BIF, CNV, and EMBO fellowships, Mareike employs cortical organoids from various species and from patients with neurodevelopmental disorders to decode the epigenetic regulation in neural stem cells.
Abstract
The neocortex is considered to be the seat of higher cognitive functions in humans. During its evolution, most notably in humans, the neocortex has undergone considerable expansion, which is reflected by an increase in the number of neurons. Epigenetic mechanisms play a pivotal role in orchestrating the behaviour of neural stem cells during development. We are interested in the mechanisms that regulate gene expression in neural stem cells, which have implications for our understanding of neocortex development and evolution, neural stem cell regulation and neurodevelopmental diseases. We employ cortical organoids from different primate species and from patients with neurodevelopmental disorders. I will present our data on the primate-expressed growth factor EPIREGULIN in neocortex evolution and our recent work addressing the role of epigenetic regulation in human cortical development.
Links
Practical information
- Informed public
- Free
Organizer
- F. Zenk, D. Jabaudon, P. Marquet, P. Magistretti, R. Du Pasquier Host: F. Zenk