NeuroNA Human Cellular Neuroscience Seminar // Silvia Cappello "Cellular Crosstalk in Brain Development, Evolution and Disease"
Stay at the forefront of neuroscience research with the NeuroNA Human Cellular Neuroscience Seminar Series. This series brings together the NeuroLéman community to explore cutting-edge developments in brain development, stem cells and organoids, and the mechanisms underlying brain and psychiatric disorders.
Seminars are held alternately at EPFL, CHUV/UNIL in Lausanne and at Campus Biotech in Geneva (EPFL/UNIGE), with the option to join online.
In this edition, we are pleased to host Silvia Cappello, Professor of Molecular Physiology of Neurogenesis at the Ludwig Maximilian University of Munich.
Her research focuses on neurogenesis in mouse and human and neurodevelopmental disorders.
Abstract
Cellular crosstalk is an essential process during brain development and is influenced by numerous factors, including cell morphology, adhesion, the local extracellular matrix and secreted vesicles. Inspired by mutations associated with neurodevelopmental disorders, we focus on understanding the role of extracellular mechanisms essential for the proper development of the human brain. Therefore, we combine 2D and 3D in vitro human models to better understand the molecular and cellular mechanisms involved in progenitor proliferation and fate, migration and maturation of excitatory and inhibitory neurons during human brain development and tackle the causes of neurodevelopmental disorders. In particular, we focus on mutations in genes affecting cell-cell contacts, extracellular matrix and vesicle secretion to study intrinsic and extrinsic mechanisms contributing to brain formation. Our data reveal an important contribution of cell-non-autonomous mechanisms in causing neurodevelopmental disorders.
Seminars are held alternately at EPFL, CHUV/UNIL in Lausanne and at Campus Biotech in Geneva (EPFL/UNIGE), with the option to join online.
In this edition, we are pleased to host Silvia Cappello, Professor of Molecular Physiology of Neurogenesis at the Ludwig Maximilian University of Munich.
Her research focuses on neurogenesis in mouse and human and neurodevelopmental disorders.
Abstract
Cellular crosstalk is an essential process during brain development and is influenced by numerous factors, including cell morphology, adhesion, the local extracellular matrix and secreted vesicles. Inspired by mutations associated with neurodevelopmental disorders, we focus on understanding the role of extracellular mechanisms essential for the proper development of the human brain. Therefore, we combine 2D and 3D in vitro human models to better understand the molecular and cellular mechanisms involved in progenitor proliferation and fate, migration and maturation of excitatory and inhibitory neurons during human brain development and tackle the causes of neurodevelopmental disorders. In particular, we focus on mutations in genes affecting cell-cell contacts, extracellular matrix and vesicle secretion to study intrinsic and extrinsic mechanisms contributing to brain formation. Our data reveal an important contribution of cell-non-autonomous mechanisms in causing neurodevelopmental disorders.
Links
Practical information
- Informed public
- Free
Organizer
- Host: Pierre Magistretti