Nuclear receptor regulation of nutrient metabolism
Event details
| Date | 11.10.2010 |
| Hour | 12:15 |
| Speaker | Dr. David J. MANGELSDORF, Professor & Chair, University of Texas Southwestern Medical Center, Dallas, TX, USA |
| Location |
SV 1717A
|
| Category | Conferences - Seminars |
The ability to regulate nutrient metabolism under conditions of excess (i.e., after a big meal) or deprivation (i.e., starvation) is a physiologic process that coincided with the evolution of nuclear receptors in all multi-cellular organisms. In mammals, nuclear receptor systems have evolved to respond to cholesterol, bile acids, and fatty acids and thereby govern nutrient metabolism in the fed and fasted state. Recently, we have discovered that this process is conserved in nematodes, and this has led to the discovery that nuclear receptor regulated pathways may be exploited therapeutically to target two unexpectedly related human diseases: type 2 diabetes and nematode parasitism.
Practical information
- General public
- Free