Organocatalysis and Central Chirality Playing Together for the Control of Axial and Helical Chiralities

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Event details

Date 25.11.2022 16:1517:15  
Speaker Prof. Jean Rodriguez Aix Marseille Université, Institut des Sciences Moléculaires de Marseille, Marseille, France
https://ism2.univ-amu.fr
Location
Génopode C
Category Conferences - Seminars
Event Language English
Organocatalysis and Central Chirality Playing Together for the Control
of Axial and Helical Chiralities

Prof. Jean Rodriguez

Aix-Marseille Université, Institut des Sciences Moléculaires de Marseille (iSm2)
Service 531, campus de St Jérôme, 13013 Marseille (France)
e-mail: [email protected]
Web: ism2.univ-amu.fr

The presentation will be devoted to our recent efforts toward the development of new enantioselective organocatalyzed synthetic sequences involving the reactivity of functionalized pronucleophiles such as 1,2-dicarbonyl, 1,3-dicarbonyl and phenol derivatives. [1]

A special focus will be given on covalent and non-covalent organocatalytic activation modes with various bifunctional organocatalyst triggering the stereocontrol of both centrally,[2] axially[3] and helically[4] chiral polyfunctionalized systems. 
 
[1]. a) For a concept article, see: D. Bonne, T. Constantieux, Y. Coquerel, J. Rodriguez, Chem. Eur. J., 2013, 19, 2218; b) for a recent monograph, see: Stereoselective multiple bond-forming transformations in organic synthesis. D. Bonne, J. Rodriguez Eds, Wiley-VCH, 2015; c) A. Quintard, D. Cheshmedzhieva, M. del Mar Sanchez Duque, A. Gaudel-Siri, J.-V. Naubron, Y. Génisson,  J.-C. Plaquevent, X. Bugaut, J. Rodriguez, T. Constantieux. Chem. Eur. J. 2015, 21, 778.
[2]. a) S. Goudedranche, X. Bugaut, T. Constantieux, D. Bonne, J. Rodriguez. Chem. Eur. J. 2014, 20, 410 ; b) C. Sasso D’Elia, S. Goudedranche, T. Constantieux, M. Bella, D. Bonne, J. Rodriguez Adv. Synth. Cat. 2017, 359, 3638 ; c) Y.-L. Wei, Y. Ren, D. Mailhol, M. Rajzmann, J. Rodriguez, Y. Coquerel, Adv. Synth. Cat. 2019, 361, 2992 ; d) Y. Zhou, Y.-L. Wei, J. Rodriguez, Y. Coquerel Angew. Chem. Int. Ed. 2019, 58, 456 ; e) R. Beaud, B. Michelet, Y. Reviriot, A. Martin-Mingot, J. Rodriguez, D. Bonne, S. Thibaudeau, Angew. Chem. Int. Ed. 2020, 59, 1279.
[3]. a) O. Quinonero, M. Jean, N. Vanthuyne, C. Roussel, D. Bonne, T. Constantieux, C. Bressy, X. Bugaut, J. Rodriguez, Angew. Chem. Int. Ed. 2016, 55, 1401; b) V. S. RautM. JeanN. VanthuyneC. RousselT. Constantieux, C. Bressy, X. Bugaut, D. Bonne, J. Am. Chem. Soc. 2017, 139, 2140 ; c) X. Bao, J. Rodriguez, D. Bonne, Chem. Sci. 2020, 11, 403. Y.-L. Wei, G. Dauvergne, J. Rodriguez, Y. Coquerel, J. Am. Chem. Soc. 2020, 142, 16921.
[4]. P. Liu, X. Bao, J.-V. Naubron, S. Chentouf, S. Humbel, N. Vanthuyne, M. Jean, L. Giordano, J. Rodriguez, D. Bonne J. Am. Chem. Soc. 2020, 142, 16199.

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