Poised Transcription Complexes In Epigenetics And Genome Function
Event details
| Date | 16.12.2009 |
| Hour | 16:30 |
| Speaker | Dr Ana Pombo |
| Location |
SV 1717A
|
| Category | Conferences - Seminars |
Our main aim is to understand the molecular and structural processes that regulate gene expression in the context of the interphase nucleus. We are investigating the relationship between genome architecture and gene expression in embryonic stem (ES) cells, differentiated systems and in neurodegeneration. We have developed high-resolution imaging methods for the visualisation of spatial relationships within the nucleus (e.g. cryo-FISH), and aim to understand the contribution of nuclear positioning on gene expression. Using chromatin immunoprecipitation (ChIP), we have shown that poised RNA polymerase II complexes are bound in ES cells at inactive, ‘bivalent’ genes that are important for early ES cell differentiation. We are currently studying their activity and regulation. We have identified poised transcription factories and are investigating their association with inducible genes.
Links
Practical information
- General public
- Free
Contact
- Caroline Guinchard