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Abstract:
Gene regulation is a multilayered process, involving hundreds of transcription factors that respond to specific signals and bind and control the activity of regulatory elements such as enhancers and promoters. In turn, enhancers and promoters communicate with each other, often over very long distances. In this seminar I will discuss three scalable technologies that our lab has developed to (1) probe the activity of many transcription factors in parallel; (2) construct detailed models of the regulatory grammar of human promoters; (3) elucidate the functional impact of the precise positioning of regulatory elements in the genome.
