Probing and modeling gene regulatory networks
Event details
| Date | 16.06.2025 |
| Hour | 16:00 › 17:00 |
| Speaker | Prof. Bas van Steensel, Netherlands Cancer Institute & Oncode Institute, Amsterdam, the Netherlands |
| Location | |
| Category | Conferences - Seminars |
| Event Language | English |
Abstract:
Gene regulation is a multilayered process, involving hundreds of transcription factors that respond to specific signals and bind and control the activity of regulatory elements such as enhancers and promoters. In turn, enhancers and promoters communicate with each other, often over very long distances. In this seminar I will discuss three scalable technologies that our lab has developed to (1) probe the activity of many transcription factors in parallel; (2) construct detailed models of the regulatory grammar of human promoters; (3) elucidate the functional impact of the precise positioning of regulatory elements in the genome.
Biography:
Bas van Steensel is Research Group Leader at the Netherlands Cancer Institute (NKI) in Amsterdam, Investigator at the Oncode Institute, and Professor at Utrecht University. He received a PhD in biochemistry at the University of Amsterdam. He had two postdoc positions, first in the lab of Titial de Lange at the Rockefeller University, and subsequently in the lab of Steven Henikoff at the Fred Hutchinson Cancer Research Center. Over the past ~20 years his lab has developed a variety of novel genomics technologies to elucidate principles of genome biology and gene regulation.
© 2025 EPFL
Gene regulation is a multilayered process, involving hundreds of transcription factors that respond to specific signals and bind and control the activity of regulatory elements such as enhancers and promoters. In turn, enhancers and promoters communicate with each other, often over very long distances. In this seminar I will discuss three scalable technologies that our lab has developed to (1) probe the activity of many transcription factors in parallel; (2) construct detailed models of the regulatory grammar of human promoters; (3) elucidate the functional impact of the precise positioning of regulatory elements in the genome.
Biography:
Bas van Steensel is Research Group Leader at the Netherlands Cancer Institute (NKI) in Amsterdam, Investigator at the Oncode Institute, and Professor at Utrecht University. He received a PhD in biochemistry at the University of Amsterdam. He had two postdoc positions, first in the lab of Titial de Lange at the Rockefeller University, and subsequently in the lab of Steven Henikoff at the Fred Hutchinson Cancer Research Center. Over the past ~20 years his lab has developed a variety of novel genomics technologies to elucidate principles of genome biology and gene regulation.
Practical information
- General public
- Free
Organizer
- Prof. Bart Deplancke
Contact
- Joanna Rusnok