Prof. Hess Bellwald's Lab: Kelly Maggs - Discrete Hodge Theory and Single Cell RNA Velocity

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Event details

Date 11.05.2022 16:0016:45  
Speaker Kelly Maggs, BMI
Category Conferences - Seminars
Event Language English

Hybrid - By  invitation only

In 2018, La Manno et al. introduced a method for approximating the velocity of RNA levels in single cells. The information in each velocity vector is comprised of a complex combination of different biological processes and noise, and in this talk, we propose a method for separating the signal into meaningful components. 

We will discuss a number of models, inspired by Topological Data Analysis, for discretizing RNA velocity. From here, one can use the tools of discrete Hodge theory which provide a natural way to deconvolve different components of the RNA velocity field. This talk will be self-contained, starting with a short introduction to simplicial complexes (which provide a discrete model of RNA expression space) and discrete Hodge theory. 
 

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Practical information

  • Informed public
  • Invitation required
  • This event is internal

Organizer

  • Brain Mind Institute

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