Regulation of DUOX and IMD pathway in Drosophila gut immunity
Event details
| Date | 29.05.2009 |
| Hour | 15:30 |
| Speaker | Won-Jae Lee |
| Location |
SV 1717A
|
| Category | Conferences - Seminars |
One of the fundamental questions relevant to all metazoans is how gut immunity manages different microbes. At present, host factors required to maintain healthy gut-microbe homeostasis are largely unknown. Here, we show that the intestinal homeobox gene Caudal (Cad) is indispensable for immune homeostasis in preserving the indigenous commensal community and host health. In a commensal-rich gut environment where the NF-kB activation is constitutive albeit at a low level, Cad maintains the minimum antimicrobial potential by repressing NF-kB-dependent antimicrobial peptide (AMP) genes. Our in vivo experiments showed that Cad is an essential determinant that regulates a delicate immune homeostasis for healthy commensal-gut interaction.
In the case of pathogen-gut interactions, however, host mounts a robust innate immunity based on reactive oxygen species (ROS) through dual oxiase (DUOX). DUOX is subjected to multiple regulations to adjust immune intensity depending on the nature of gut-microbe interactions. Multiple regulations of DUOX and their in vivo values will also be discussed.
These results reveal that multiple regulations of signaling leading to ROS and AMP generation within a host enable the protection of beneficial flora as well as efficient elimination of transient microbes, which ultimately influences host physiology.
Links
Practical information
- General public
- Free
Contact
- Prof. Bruno Lemaitre - Global Health Institute