Conferences - Seminars

  Thursday 22 March 2018 10:15 SV 1717

Regulation of Liver Sex-Dimorphic Gene Expression and Metabolism by Gut Microbiota

By Frédéric Gachon, Ph.D., EPFL


Gut microbiota and the circadian clock are both key regulators of metabolic processes. Although recent evidence points to the impact of the circadian clock on microbiota, gut microbiota effect on diurnal host gene expression remains elusive. A transcriptome analysis of germ-free mice reveals subtle changes in circadian clock gene expression in liver, intestinal, and white adipose tissue. However, a lack of microbiome leads to the loss of liver sex-dimorphism and alters the sex-specific rhythmic expression of genes involved in lipid, amino acid, and pyridine metabolism, as well as xenobiotic detoxification. Consequently, rhythmic sex-dimorphic metabolism is also strongly altered in germ-free mice. Additional evidences suggest that exposure to microbiota-derived metabolites is required for the maturation of the pituitary, in addition to the activation of a subset of signaling pathway in adults. As a consequence, sex-dimorphic growth hormone and sex hormones secretion is altered in germ free mice, leading to the observed loss of liver sex-dimorphism. These results emphasize the mutual interaction of gut microbiota and its host even on unexpected functions.



Nov 2017 – Present
Senior Scientist

Nov 2014 – Present
Maître d'Enseignement et de Recherche

Sept 2012 – Present
Senior Expert
Company Name Nestlé Institute of Health Sciences

Sept 2009 – Aug 2012
Assistant professor
Université de Lausanne

Jul 2006 – Aug 2009
Research Group Leader

Oct 2001 – Jul 2006
Post-doctoral assistant
Université de Genève


2008 – 2009
University of Montpellier
HDR Degree, Biochemistry-Molecular Biology

1997 – 2001
University of Montpellier
PhD, Biochemistry-Molecular Biology

University of Montpellier
DEA, Biologie-Santé

1994 – 1997
Ecole Nationale Supérieure de Chimie de Montpellier
Master degree, Chemistry

1992 – 1994
Aix-Marseille University
DUT Degree, Chemistry

Organization Prof. Felix Naef

Contact Prof. Felix Naef

Accessibility Informed public

Admittance Free