Regulation of proteasome activity – the role of insulin/IGF-1 signaling
Event details
| Date | 10.07.2013 |
| Hour | 10:30 › 11:30 |
| Speaker |
Olli MATILAINEN, M.Sc. Research Programs Unit, Translational Cancer Biology Research Program, Biomedicum Helsinki University of Helsinki, Finland |
| Location | |
| Category | Conferences - Seminars |
LIMNA seminar - Lausanne Integrative Metabolism and Nutrition Alliance
The proteasome is responsible for the major part of controlled protein degradation in the cell, and impairments in its function have been associated with many severe, usually age-related disorders. By using C. elegans as model organism, we found that aging-related insulin/IGF-1 signaling (IIS) regulates proteasome activity through SKN-1 and DAF-16 transcription factors. Moreover, we discovered that DAF-16 regulates the expression of proteasome-associated deubiquitinating enzyme ubh-4, which we show functioning as a tissue-specific proteasome regulator. Altogether, our results establish a mechanism linking IIS to proteasome activity and add one more branch to IIS mediated maintenance of cellular protein homeostasis.
The proteasome is responsible for the major part of controlled protein degradation in the cell, and impairments in its function have been associated with many severe, usually age-related disorders. By using C. elegans as model organism, we found that aging-related insulin/IGF-1 signaling (IIS) regulates proteasome activity through SKN-1 and DAF-16 transcription factors. Moreover, we discovered that DAF-16 regulates the expression of proteasome-associated deubiquitinating enzyme ubh-4, which we show functioning as a tissue-specific proteasome regulator. Altogether, our results establish a mechanism linking IIS to proteasome activity and add one more branch to IIS mediated maintenance of cellular protein homeostasis.