Regulation of Translation in Relation to Cell Fate
Event details
| Date | 07.09.2018 |
| Hour | 11:00 › 12:00 |
| Speaker | Prof. Mihaela Zavolan, Biozentrum, University of Basel (CH) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
Cell type specification has been primarily attributed to epigenetic and transcriptional regulation. However, translation regulation is prominent in early development and several recent studies have linked alterations in protein synthesis to changes in cell functionality. Furthermore, evidence is accumulating that ribosome variants contribute to cell type-specific programs of gene expression. In this talk I would like to present our efforts in characterizing the regulation of mRNA translation in relation to cellular states, from yeast to man. I will describe our work on inferring determinants of protein synthesis rates in yeast, as well as the relationship between protein synthesis capacity and lifespan. I will also discuss aspects of translation regulation in mammalian system, specifically relative to cell type and the proliferation rate of cells.
Bio:
Positions:
Since 2014 Professor in Computational Biology/Genomics, Biozentrum, University of Basel
2008 – 2014 Associate Professor in Computational and Systems Biology, Biozentrum, University of Basel
2003 – 2008 Assistant Professor in Computational and Systems Biology, Biozentrum, University of Basel
Since 2003 Group leader at the SIB Swiss Institute of Bioinformatics
2000 – 2003 Postdoctoral Fellow in the Laboratory of Computational Biology, The Rockefeller University, NY, USA.
1999 – 2000 Postdoctoral fellow in the division of theoretical biology and biophysics, Los Alamos National Laboratory, NM, USA
1996 – 1999 Teaching assistant and lecturer for the introductory programming class at Computer Science Department, University of New Mexico, Albuquerque, NM, USA
1994 – 1996 Research associate at the division of Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
1993 – 1994 Research associate, Theoretical Immunology Program, The Santa Fe Institute, Santa Fe, NM, USA
Education:
Since 1999 Ph.D. in Computer Science, University of New Mexico, Albuquerque, NM, USA in the group of Dr. Stephanie Forrest.
Since 1996 M. Sc. in Computer Science, University of New Mexico, Albuquerque, NM, USA
Since 1992 MD at the Univeristy of Medicine and Pharmacy of Timisoara, Romania.
Abstract:
Cell type specification has been primarily attributed to epigenetic and transcriptional regulation. However, translation regulation is prominent in early development and several recent studies have linked alterations in protein synthesis to changes in cell functionality. Furthermore, evidence is accumulating that ribosome variants contribute to cell type-specific programs of gene expression. In this talk I would like to present our efforts in characterizing the regulation of mRNA translation in relation to cellular states, from yeast to man. I will describe our work on inferring determinants of protein synthesis rates in yeast, as well as the relationship between protein synthesis capacity and lifespan. I will also discuss aspects of translation regulation in mammalian system, specifically relative to cell type and the proliferation rate of cells.
Bio:
Positions:
Since 2014 Professor in Computational Biology/Genomics, Biozentrum, University of Basel
2008 – 2014 Associate Professor in Computational and Systems Biology, Biozentrum, University of Basel
2003 – 2008 Assistant Professor in Computational and Systems Biology, Biozentrum, University of Basel
Since 2003 Group leader at the SIB Swiss Institute of Bioinformatics
2000 – 2003 Postdoctoral Fellow in the Laboratory of Computational Biology, The Rockefeller University, NY, USA.
1999 – 2000 Postdoctoral fellow in the division of theoretical biology and biophysics, Los Alamos National Laboratory, NM, USA
1996 – 1999 Teaching assistant and lecturer for the introductory programming class at Computer Science Department, University of New Mexico, Albuquerque, NM, USA
1994 – 1996 Research associate at the division of Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
1993 – 1994 Research associate, Theoretical Immunology Program, The Santa Fe Institute, Santa Fe, NM, USA
Education:
Since 1999 Ph.D. in Computer Science, University of New Mexico, Albuquerque, NM, USA in the group of Dr. Stephanie Forrest.
Since 1996 M. Sc. in Computer Science, University of New Mexico, Albuquerque, NM, USA
Since 1992 MD at the Univeristy of Medicine and Pharmacy of Timisoara, Romania.
Practical information
- Informed public
- Free