Renovating Optofluidic Biomolecular Sensing
Event details
| Date | 27.05.2025 |
| Hour | 10:00 › 11:00 |
| Speaker | Prof. Xiaotian Tan, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen (China) |
| Location | |
| Category | Conferences - Seminars |
| Event Language | English |
BIOENGINEERING SEMINAR
Abstract:
Biomolecular sensing is undergoing a transformative shift as emerging technologies challenge the limitations of conventional platforms. This presentation outlines a renovation framework centered on three core components: molecular recognition, reaction optimization, and signal transduction. We have recently developed the Tip Optofluidic Immunoassay (TOI), a compact, microliter-scale platform enabling multiplexed immune profiling from fingertip blood. As we demonstrated in COVID-19 and tuberculosis studies, TOI enables rapid, quantitative assessment of both antibody and T-cell responses. Additionally, a new class of synthetic biology-based biomolecular probes—“sensobodies”—has been developed by fusing target-specific recognition domains with engineered anchoring peptides. This modular architecture supports precise surface integration, enhanced stability, and tunable binding affinity. Collectively, these innovations point toward a new generation of optofluidic biosensors with improved adaptability, sensitivity, and clinical utility in infectious disease monitoring and personalized diagnostics.
Abstract:
Biomolecular sensing is undergoing a transformative shift as emerging technologies challenge the limitations of conventional platforms. This presentation outlines a renovation framework centered on three core components: molecular recognition, reaction optimization, and signal transduction. We have recently developed the Tip Optofluidic Immunoassay (TOI), a compact, microliter-scale platform enabling multiplexed immune profiling from fingertip blood. As we demonstrated in COVID-19 and tuberculosis studies, TOI enables rapid, quantitative assessment of both antibody and T-cell responses. Additionally, a new class of synthetic biology-based biomolecular probes—“sensobodies”—has been developed by fusing target-specific recognition domains with engineered anchoring peptides. This modular architecture supports precise surface integration, enhanced stability, and tunable binding affinity. Collectively, these innovations point toward a new generation of optofluidic biosensors with improved adaptability, sensitivity, and clinical utility in infectious disease monitoring and personalized diagnostics.
Practical information
- Informed public
- Free
Organizer
Contact
- Marie Rodriguez