“Role of sleep and oscillations in memory”
Event details
| Date | 13.04.2012 |
| Hour | 11:00 › 12:00 |
| Speaker |
Karim Benchenane, PhD. UMR 7102 CNRS-Université Pierre et Marie Curie, Paris |
| Location |
SV1717A
|
| Category | Conferences - Seminars |
Memory is a dynamical phenomenon, from the moment of encoding to retrieval. After encoding, labile memories undergo consolidation, that is, they stabilize over time. The Buzsaki’s hypothesis (1989) proposed that encoding occurs during awake hippocampal theta (5-10Hz) oscillations, and consolidation during slow wave sleep, involving reactivations that occur during hippocampal 200Hz oscillations called the sharp-waves-ripples complexes. We first showed that the two-stage memory consolidation theory does not only rely on the sole hippocampus (as initially proposed) but can also be extended to the hippocampal-prefrontal network, and proposed that dopamine could be a key actor of this process (Benchenane et al. Neuron 2010, Benchenane et al. Curr Opinion Neurobiol 2011, Peyrache, et al. Nat Neurosci 2009; Battaglia et al., Trends Cogn Sci 2011). The second main finding of my studies was to identify the causal role of ripples on learning and memory consolidation (Girardeau*, Benchenane* et al., Nat Neurosci 2009, *co-authorship). We indeed showed that reactivations during sleep are necessary to memory consolidation as subsequent performance depends on ripple events. My current work focuses on the other potential roles of sleep in cognitive processes.
Practical information
- General public
- Free
Organizer
- BMI - LNDC : "Sleep & Astrocytes Seminars Series"
Contact
- Jean-Marie Petit