Single Molecule Biophysics from Single Ions to Protein Clusters: When Less is More
Event details
| Date | 16.06.2016 |
| Hour | 17:15 |
| Speaker | Prof. Aleksandra Radenovic, Institute of Bioengineering, EPFL |
| Location | |
| Category | Conferences - Seminars |
INAUGURAL LECTURE
Abstract:
Many processes within the cell are carried out by very few molecules. By studying single molecules, it is possible to obtain details about the mechanism of a reaction that cannot be ascertained by studying a population of molecules.Insights into complex behavior can be gained through manipulation, imaging or sensing of single biomolecules.
Single-molecule techniques can provide us with extraordinarily clear and often surprising views of biomolecules in action. Development of appropriate instrumentation has been identified as the key ingredient for advances in biophysical sciences. Three most important examples here are single molecule localization microscopy (SMLM), optical tweezers and nanopores. SMLM made it possible to "see" by visualizing single fluorophores in living cells while laser-based optical tweezers allowed us to "touch" with experiments on physical forces involved in stretching and binding of biomolecules, while nanopores, the simplest and the most recent single molecule technique allows for rapid and high-throughput biosensing and detection of atto-molar molecule concentrations.We use novel solid state nanopore platform based on atomically thin nanopore membranes in 2D materials such as graphene or molybdenum disulfide for DNA detection, sequencing, water desalination and osmotic power generation.
Program:
- Introduction by Prof. Demetri Psaltis, Dean of The School of engineering (STI)
- Inaugural Lecture of Aleksandra Radenovic: "Single Molecule Biophysics from Single Ions to Protein Clusters: When Less is More"
Please register here: http://go.epfl.ch/radenovic
Bio:
Aleksandra Radenovic received her master's degree in physics from the University of Zagreb in 1999 before joining Professor Giovanni Dietler's Laboratory of Physics of Living Matter in 2000 at University of Lausanne. There she earned her Doctor of Sciences degree in 2003. In 2003 she was also awarded a research scholarship for young researchers from the Swiss Foundation for Scientific Research which allowed her to spend 3 years as postdoctoral fellow at the University of California, Berkeley (2004‐2007).
Before joining EPFL as Assistant Professor in 2008 she spent 6 months at NIH and Janelia Farm. In 2010 she received the ERC starting grant and in 2015 SNSF Consolidator grant. Her group is interested in using novel nanomaterials and single molecule experimental techniques to study fundamental questions in molecular and cell biology.
Abstract:
Many processes within the cell are carried out by very few molecules. By studying single molecules, it is possible to obtain details about the mechanism of a reaction that cannot be ascertained by studying a population of molecules.Insights into complex behavior can be gained through manipulation, imaging or sensing of single biomolecules.
Single-molecule techniques can provide us with extraordinarily clear and often surprising views of biomolecules in action. Development of appropriate instrumentation has been identified as the key ingredient for advances in biophysical sciences. Three most important examples here are single molecule localization microscopy (SMLM), optical tweezers and nanopores. SMLM made it possible to "see" by visualizing single fluorophores in living cells while laser-based optical tweezers allowed us to "touch" with experiments on physical forces involved in stretching and binding of biomolecules, while nanopores, the simplest and the most recent single molecule technique allows for rapid and high-throughput biosensing and detection of atto-molar molecule concentrations.We use novel solid state nanopore platform based on atomically thin nanopore membranes in 2D materials such as graphene or molybdenum disulfide for DNA detection, sequencing, water desalination and osmotic power generation.
Program:
- Introduction by Prof. Demetri Psaltis, Dean of The School of engineering (STI)
- Inaugural Lecture of Aleksandra Radenovic: "Single Molecule Biophysics from Single Ions to Protein Clusters: When Less is More"
Please register here: http://go.epfl.ch/radenovic
Bio:
Aleksandra Radenovic received her master's degree in physics from the University of Zagreb in 1999 before joining Professor Giovanni Dietler's Laboratory of Physics of Living Matter in 2000 at University of Lausanne. There she earned her Doctor of Sciences degree in 2003. In 2003 she was also awarded a research scholarship for young researchers from the Swiss Foundation for Scientific Research which allowed her to spend 3 years as postdoctoral fellow at the University of California, Berkeley (2004‐2007).
Before joining EPFL as Assistant Professor in 2008 she spent 6 months at NIH and Janelia Farm. In 2010 she received the ERC starting grant and in 2015 SNSF Consolidator grant. Her group is interested in using novel nanomaterials and single molecule experimental techniques to study fundamental questions in molecular and cell biology.
Practical information
- General public
- Free
Organizer
- Sylvie Deschamps