Sirtuin 2 and insulin resistance: is there a connection?
Event details
| Date | 13.08.2013 |
| Hour | 10:30 › 11:30 |
| Speaker |
Vera LEMOS, University of Porto, Portugal Bio: I am Vera Lemos and I graduated in Nutritional Sciences by University of Porto. For the past 2 years, I have been investigating the role of Sirtuins on metabolism, trying to emphasize their activation as a therapeutic strategy for the treatment of metabolic diseases. After this, I was willing to get to know other areas of research to enrich my scientific knowledge and to try to engage in my PhD with a novel multidisciplinary approach, so I joined GABBA at the University of Porto. |
| Location | |
| Category | Conferences - Seminars |
Since the beginning of this century, the sirtuin family (SIRT1–SIRT7) of mammalian NAD+-dependent deacetylases and/or ADP ribosyltransferases has received much attention for its regulatory role in a plethora of cellular functions. The dependence of sirtuins on NAD+ links their enzymatic activity to cellular metabolic status. Indeed, emerging evidence suggests a role for sirtuins in the regulation of various metabolic pathways in response to nutrient availability. Our results showed that SIRT2 expression is downregulated in insulin-resistant cells and tissues, and this is paralleled by increased oxidative stress levels and mitochondrial dysfunction. By using in vitro cell based studies complemented with whole animal and human studies, we aimed at strengthening SIRT2’s position as a future target for the prevention and/or treatment of the current epidemic of metabolic disorders, such as insulin resistance.
Links
Practical information
- Informed public
- Free
- This event is internal
Organizer
- Profs. Kristina Schoonjans and Johan Auwerx