STEPS: REACTION-DIFFUSION SIMULATION IN COMPLEX 3D GEOMETRIES
Event details
| Date | 04.02.2010 |
| Hour | 14:30 |
| Speaker | Prof. Erik De Schutter, Computational Neuroscience Unit, Okinawa, Japan, Theoretical Neurobiology, University of Antwerp, Belgi |
| Location |
AI 1-153
|
| Category | Conferences - Seminars |
I will give an overview of the STEPS software and present preliminary data on using STEPS to model the stochastic induction of cerebellar long-term depression (LTD). STEPS (STochastic Engine for Pathway Simulation) is a platform for simulation of signalling pathways where the spatial organization and morphology of the cell can be represented by complex 3D tetrahedral meshes. Our core algorithm is based on Gillespie’s Direct Method extended for membrane reactions and diffusive fluxes between tetrahedral voxels. I'll demonstrate our use of STEPS to simulate anomalous diffusion in Purkinje cell spiny dendrites and to simulate the signaling pathways involved in the induction of LTD at the parallel fiber to Purkinje cell synapse.
Practical information
- General public
- Free