Structural studies of complexes involved in regulation of gene expression

The Nogales lab has used crystallographic and cryo-electron microscopic approaches to solve the structure of microtubules and associated proteins (e.g. Cell 162:849, 2015), with more recent forays in other territories, including the architecture of the transcription pre-initiation complex (e.g. Nature 531: 604, 2016), which will be the focus of her presentation next week.

Bio: Eva Nogales is a Howard Hughes Medical Institute investigator; a Professor of Biochemistry and Molecular Biology at the University of California, Berkeley; and Senior Faculty Scientist at the Lawrence Berkeley National Laboratory. She obtained her B.S. degree in physics from the Universidad Autonoma de Madrid (Spain). She did her thesis work at the Synchrotron Radiation Source (U.K.), under the supervision of Joan Bordas, on the structural dynamics of tubulin assembly, earning a Ph.D. degree from the University of Keele. Her work in Kenneth Downing's group at the Lawrence Berkeley National Laboratory involved the use of electron crystallography to determine the high-resolution structure of tubulin.