Study of resilience, a second dimension of host defense, in intestinal infections of the genetic model organism Drosophila melanogaster
Event details
| Date | 19.01.2015 |
| Hour | 10:15 › 11:15 |
| Speaker | Dominique Ferrandon |
| Location | |
| Category | Conferences - Seminars |
Host defense is not limited to immunity and encompasses the ability to endure and repair damages and to handle toxins and toxicants. After a general introduction on the Drosophila model and the notion of resilience to infections, I will describe the existence in the fly intestine of a common response to Serratia marcescens hemolysin, a pore-forming toxin, and to xenobiotics such as caffeine, soft or heavy metals, or a strong oxidant. Exposure of enterocytes to hemolysin leads to the rapid formation of megamitochondria and a subsequent controlled extrusion of the cytoplasm along with damaged organelles, which may constitute a novel repair mechanism. This results in a thin intestinal epithelium that recovers its original shape in a few hours. The recovery process requires CyclinJ, an evolutionary conserved cyclin of hitherto unknown function. Finally, a primary exposure to toxin or xenobiotics induces cross-protection against a further hemolysin challenge, thus evoking a hormetic response, which can be elicited by ectopically expressing what else, a CyclinJ-dependent gene. Thus, CyclinJ plays a central role in this novel resilience mechanism that defends the intestine against infections or intoxications.
Practical information
- General public
- Free
Organizer
Bruno Lemaitre (UPLEM)
Contact
- Bruno Lemaitre (UPLEM)