Conferences - Seminars

  Thursday 17 May 2018 15:15 SV 1717

Synthetic Approaches to Musculoskeletal Tissue Regeneration

By Prof. Hala Zreiqat, University of Sydney (AUS)


The repair and regeneration of large bone defects under load has remained a major clinical challenge for orthopaedic surgeons. In addition, the development of suitable synthetic scaffolds for use as tendon and ligament (T/L) prosthesis to treat T/L ruptures remains a significant challenge. This presentation will describe our strategies in synthetic platform to develop cell-free therapeutics to promoting bone and tendon regeneration in these challenging situations.
This presentation will discuss our three dimensional (3D) printed ceramic scaffold and their efficacy in treating large bone defects under load. Moreover, we demonstrated that manipulating pore size and permeability, as a function of scaffold architecture, provides a useful strategy for enhancing bone regeneration outcomes.  The presentation will discuss our engineering solution to develop synthetic T/L prostheses, based on fibre-reinforced hydrogels that mimic the hierarchical structure of the native human tendon.  The composition of this new tendon and ligament allows for high strength and good in vivo tissue integration.
Our technologies open avenues for skeletal and soft tissue regeneration in various clinical applications.

Hala Zreiqat is a professor of biomedical engineering at the University of Sydney and both a National Health and Medical Research Council Senior Research Fellow (2016-2020); Director of the Australian Research Training Centre for Innovative Bio-Engineering; Co-Director of the Shanghai-Sydney Joint Bioengineering and Regenerative Medicine Lab at Shanghai JiaoTong; Honorary Professor Shanghai Jiao Tong University and Adjunct Professor Drexel University. She is the 2018 New South Wales Premier’s Woman of the Year.
Her research is on the development of novel engineered materials and 3D-printed platforms for regenerative medicine, particularly in orthopaedic, dental, and maxillofacial applications. She has established national and international industry collaborations to translate her discoveries into approved medical devices. Her pioneering development of innovative biomaterials for tissue regeneration has led to one awarded (US) and 7 provisional patents, and several collaborations with inter/national industry partners.  She has been awarded more than $17 M in competitive funding including from the NHMRC, ARC and the NSW Medical Devices Fund. She is the past president of the Australian & New Zealand Orthopaedic Research Society; founder and Chair of the Alliance for Design and Application in Tissue Engineering (ADATE) (2006-present); founder of IDEAL Society (Inclusion, Diversity, Equity, Action Leadership) at Harvard University (October 2017-); member of the National Health and Medical Research Senior Research grant review panel, the Australian Research Council Expert College and German Research Foundation. Prof. Zreiqat’s overall objective is to advance collaborative research ventures and build educational and industry linkages nationally and internationally in the field of musculoskeletal disorders and biomaterials research.

Organization Prof. Dominique Pioletti

Contact Institute of Bioengineering (IBI, Dietrich REINHARD)

Accessibility Informed public

Admittance Free