Synthetic Human Embryo-Like Structure: A New Paradigm for Human Embryology
Event details
| Date | 30.08.2019 |
| Hour | 10:00 |
| Speaker | Prof. Jianping Fu, University of Michigan, Ann Arbor, MI (USA) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
Early human embryonic development remains mysterious due to drastic species divergences between humans and other mammalian models and limited accessibility to human embryo samples. Recent studies from my laboratory and others have shown that under suitable culture conditions human pluripotent stem cells (hPSCs) can undergo intricate morphogenetic events and self-organize to form patterned human embryo-like structures in vitro. These synthetic human embryonic-like tissues hold great promises for advancing human embryology and reproductive medicine. In this talk, I will describe a hPSC-based, synthetic 3D model of human post-implantation development that recapitulates key developmental landmarks successively, including pro-amniotic cavity formation, amniotic ectoderm-epiblast patterning, primordial germ cell specification, and development of the primitive streak with controlled anteroposterior polarity. We further show that the amniotic ectoderm, as the first lineage that segregates from the epiblast upon implantation of the human embryo, functions as a signaling center to trigger primitive streak development in the epiblast. Together, our research has developed a powerful synthetic embryological model and provided new understandings of previously inaccessible but critical embryogenic events in human development.
Bio:
Jianping Fu is currently an Associate Professor at the University of Michigan, Ann Arbor, with a primary appointment in the Mechanical Engineering Department and courtesy appointments in the Biomedical Engineering Department and the Cell and Developmental Biology Department. He is a Core Faculty Member for the UM Center for Organogenesis, the UM Comprehensive Cancer Center, and the UM Center for Systems Biology. Dr. Fu received a B.E. degree (2000) from the University of Science and Technology of China (USTC) and a M.S. degree (2002) from the University of California at Los Angeles (UCLA), both in Mechanical Engineering. He earned his Ph.D. degree in Mechanical Engineering from the Massachusetts Institute of Technology (MIT) in 2007 for thesis completed with Dr. Jongyoon Han. Dr. Fu was an American Heart Association Postdoctoral Fellow in Dr. Christopher S. Chen's group at the University of Pennsylvania from 2007 to 2009.
Abstract:
Early human embryonic development remains mysterious due to drastic species divergences between humans and other mammalian models and limited accessibility to human embryo samples. Recent studies from my laboratory and others have shown that under suitable culture conditions human pluripotent stem cells (hPSCs) can undergo intricate morphogenetic events and self-organize to form patterned human embryo-like structures in vitro. These synthetic human embryonic-like tissues hold great promises for advancing human embryology and reproductive medicine. In this talk, I will describe a hPSC-based, synthetic 3D model of human post-implantation development that recapitulates key developmental landmarks successively, including pro-amniotic cavity formation, amniotic ectoderm-epiblast patterning, primordial germ cell specification, and development of the primitive streak with controlled anteroposterior polarity. We further show that the amniotic ectoderm, as the first lineage that segregates from the epiblast upon implantation of the human embryo, functions as a signaling center to trigger primitive streak development in the epiblast. Together, our research has developed a powerful synthetic embryological model and provided new understandings of previously inaccessible but critical embryogenic events in human development.
Bio:
Jianping Fu is currently an Associate Professor at the University of Michigan, Ann Arbor, with a primary appointment in the Mechanical Engineering Department and courtesy appointments in the Biomedical Engineering Department and the Cell and Developmental Biology Department. He is a Core Faculty Member for the UM Center for Organogenesis, the UM Comprehensive Cancer Center, and the UM Center for Systems Biology. Dr. Fu received a B.E. degree (2000) from the University of Science and Technology of China (USTC) and a M.S. degree (2002) from the University of California at Los Angeles (UCLA), both in Mechanical Engineering. He earned his Ph.D. degree in Mechanical Engineering from the Massachusetts Institute of Technology (MIT) in 2007 for thesis completed with Dr. Jongyoon Han. Dr. Fu was an American Heart Association Postdoctoral Fellow in Dr. Christopher S. Chen's group at the University of Pennsylvania from 2007 to 2009.
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI), Christina Mattsson