Systemic Inactivation of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in Metabolism and Liver Diseases
Event details
| Date | 14.02.2020 |
| Hour | 11:00 › 12:00 |
| Speaker | Anna Laitakari, Ph.D., Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland |
| Location | |
| Category | Conferences - Seminars |
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)
Abstract:
Activation of the hypoxia response pathway leads to metabolic reprogramming in cells and tissues, which associates with a lower risk of cardiovascular diseases and obesity in people living at high altitude. Therefore, the Hif-p4h-2 inhibition induced HIF stabilization provides interesting opportunities to study its potential in liver diseases, often associated with the above-mentioned conditions. Our research group has shown that Hif-p4h-2 inhibition protects mice against metabolic disorder. Therefore, we set out to investigate the effects of genetic and pharmacologic inhibition of HIF-P4H-2 in AFLD and NAFLD. Moreover, it was of interest to study whether this protection against fatty liver would result in less liver cancer at old age, or alternatively, since intratumoral HIF stabilization associates with mortality in cancers, whether chronic HIF-P4H-2 inhibition would support cancer development, and lead to a reduced life span.
Abstract:
Activation of the hypoxia response pathway leads to metabolic reprogramming in cells and tissues, which associates with a lower risk of cardiovascular diseases and obesity in people living at high altitude. Therefore, the Hif-p4h-2 inhibition induced HIF stabilization provides interesting opportunities to study its potential in liver diseases, often associated with the above-mentioned conditions. Our research group has shown that Hif-p4h-2 inhibition protects mice against metabolic disorder. Therefore, we set out to investigate the effects of genetic and pharmacologic inhibition of HIF-P4H-2 in AFLD and NAFLD. Moreover, it was of interest to study whether this protection against fatty liver would result in less liver cancer at old age, or alternatively, since intratumoral HIF stabilization associates with mortality in cancers, whether chronic HIF-P4H-2 inhibition would support cancer development, and lead to a reduced life span.
Practical information
- Informed public
- Free
Organizer
- Prof. Kristina Schoonjans (on behalf of the Lausanne Integrative Metabolism and Nutrition Alliance - LIMNA)
Contact
- (*) IMPORTANT NOTICE: All external participants have to pass through SV Reception/Welcome Desk to be able to access to AI 1153. Contact person to call at arrival at SV Reception Desk: Administrative Assistant, ext. 39522.