Target Advancement: Tool Generation and Target Validation


Event details

Date 28.09.2021  
Category Call for proposal
Event Language English
Aim: The Target Advancement Program seeks to build conclusive evidence around and develop field-enabling tools for early-stage biological targets in Parkinson’s Disease (PD) in order to enable the initiation of future preclinical therapeutic programs focused on those targets. Funding will support projects to
validate early-stage targets previously implicated in PD pathophysiology and/or symptomology but that have not yet been rigorously investigated for their ability to impact disease-relevant outcomes in PD model systems. For targets that are lacking preclinical tools and/or models required for validation, the Tool Generation track provides funding for the development of research-enabling preclinical tools and models to assist with the validation of the selected target.

For this round, MJFF will not consider proposals focused on the following:
  • Validation of well-known targets, including alpha-synuclein, LRRK2, GBA and Parkin/PINK1 given significant current investments MJFF is already making in these areas.
  • Applications proposing discovery studies to identify new targets (e.g., large-scale screening or genomic/transcriptomic analyses).
Amount: Up to $200,000. Requested support should be commensurate with work proposed.
Duration: 18 to 24 months
  • Pre-proposals Due: 28 September 2021, 5 p.m. US ET
  • Full Proposals Due (by invite only): January 13, 2022, 5 p.m. US ET
Eligibility: Applications may be submitted by researchers or clinicians in:
  • U.S. and non-U.S. biotechnology/pharmaceutical companies, or other publicly or privately held for-profit entities; and
  • U.S. and non-U.S. public and private non-profit entities, such as universities, colleges, hospitals, laboratories, units of state and local governments and eligible agencies of the federal government.
  • Post-doctoral fellows are eligible to apply as co-investigators with the designation of an administrative primary investigator who directs the laboratory in which the fellow will conduct research. The administrative co-PI will be responsible for assisting in providing all institutional documents required for the project and will be required to sign any award contract. Training or mentoring-only proposals will not be considered.
How to Apply: For further Information:

Practical information

  • General public
  • Free


  • The Research Office


Parkinson's Disease model systemsalpha-synuclein LRRK2 GBA PRKN and PINK

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