The NAD World: Systemic Control of Metabolism and Aging by SIRT1 and NAMPT-Mediated NAD Biosynthesis in Mammals
Event details
| Date | 20.08.2010 |
| Hour | 11:45 |
| Speaker | Dr. Shin-ichiro IMAI M.D, Ph.D., Associate Professor, Dept Dev. Biology & Medicine, Univ Washington, St Louis, MO, USA |
| Location | |
| Category | Conferences - Seminars |
The mammalian NAD-dependent protein deacetylase SIRT1 and nicotinamide phosphoribosyltransferase (NAMPT)-mediated systemic NAD biosynthesis together play a critical role in the regulation of metabolism and aging in mammals. We have proposed a comprehensive concept of a novel systemic regulatory network connecting metabolism and aging in mammals, named the "NAD World." The aging-regulatory hierarchy of tissues/organs in the NAD World, particularly focusing on the function of SIRT1 in the hypothalamus, will be discussed.
Practical information
- General public
- Free