The plasticity of aging
Event details
| Date | 25.08.2011 |
| Hour | 10:00 |
| Speaker | Dr. Anne BRUNET Assistant Professor of Genetics, Stanford University School of Medicine, Stanford, CA, USA |
| Location | |
| Category | Conferences - Seminars |
Aging, long thought to be solely the byproduct of “wear and tear”, is in fact a highly plastic process regulated by a combination of genetic and environmental factors. My lab is interested in discovering genes that regulate lifespan and in exploring how the products of these genes integrate environmental stimuli that promote longevity, such as dietary restriction. The pathway connecting the insulin signaling pathway to FoxO transcription factors is well known to play a pivotal role in aging from worms to mammals. One part of my lab is focused on understanding how the insulin-FoxO pathway acts to regulate gene expression programs and cellular responses that are important for longevity in mammals. We are particularly interested in the role of longevity genes and pathways, including the insulin-FoxO pathway, in aging neural stem cells. My lab also uses unbiased approaches in the nematode C. elegans and in mammalian cells to identify novel pathways that control organismal longevity, particularly in response to dietary restriction. Finally, we are developing the extremely short-lived African killifish N. furzeri as a new vertebrate model for aging studies to explore the genetic architecture of longevity in vertebrates.
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Practical information
- General public
- Free