The Randle cycle revisited: direct regulation of anabolic and catabolic pathways in skeletal muscle by PGC-1alpha
Event details
| Date | 14.12.2010 |
| Hour | 11:00 |
| Speaker | Dr. Christoph HANDSCHIN - University of Basel, Switzerland |
| Location | |
| Category | Conferences - Seminars |
The peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is a central regulator of fiber plasticity in endurance-trained skeletal muscle. Upon activation by physical activity, PGC-1alpha controls the metabolic and myofibrillar programs that are prototypical of oxidative, high-endurance muscle fibers. We now provide evidence that in addition to boosting lipid oxidation, PGC-1alpha also directly regulates anabolic pathways in muscle, in particular de novo lipogenesis. Thereby, storage of lipids is promoted; these triglycerides are the substrates for ATP generation during endurance exercise bouts in trained athletes. Our findings have important cautionary implications for the development and application of "exercise mimetics", drugs that are designed to elicit an endurance-trained phenotype even in sedentary individuals.
Practical information
- General public
- Free