“The role of the Nrf2 transcription factor in liver homeostasis and regeneration”
Event details
| Date | 12.05.2015 |
| Hour | 10:00 › 11:00 |
| Speaker | Ulrike Köhler, Institute of Molecular Health Sciences, ETHZ, Zurich (CH) |
| Location | |
| Category | Conferences - Seminars |
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)
Abstract:
Oxidative stress inhibits liver regeneration and plays a crucial role in the development of chronic liver disease. As pharmacological activation of the antioxidant Nrf2 transcription factor is a promising strategy to prevent toxin-induced liver damage, we aimed to study effects of continous Nrf2 activation in the liver. We analysed mice expressing a constitutively active Nrf2 mutant in hepatocytes and found unexpected deleterious effects on liver regeneration. Furthermore, we generated mice lacking both Nrf2 and p65/RelA signalling in hepatocytes to identify potential complementary cytoprotective functions. These mice developed spontaneous liver inflammation and fibrosis, providing evidence for a functional interaction of Nrf2 and NF-kB signaling in the liver in vivo.”
Abstract:
Oxidative stress inhibits liver regeneration and plays a crucial role in the development of chronic liver disease. As pharmacological activation of the antioxidant Nrf2 transcription factor is a promising strategy to prevent toxin-induced liver damage, we aimed to study effects of continous Nrf2 activation in the liver. We analysed mice expressing a constitutively active Nrf2 mutant in hepatocytes and found unexpected deleterious effects on liver regeneration. Furthermore, we generated mice lacking both Nrf2 and p65/RelA signalling in hepatocytes to identify potential complementary cytoprotective functions. These mice developed spontaneous liver inflammation and fibrosis, providing evidence for a functional interaction of Nrf2 and NF-kB signaling in the liver in vivo.”
Practical information
- Informed public
- Free
Organizer
- Kristina Schoonjans and Johan Auwerx (for the LIMNA Alliance)
Contact
- Kristina Schoonjans and Johan Auwerx
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