Transcription Factors As Sensors and Modifiers of Chromatin
Event details
| Date | 16.10.2019 |
| Hour | 11:00 › 12:00 |
| Speaker | Prof. Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research, Basel (CH) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
Transcription factors only bind a minority of their motifs in large mammalian genomes. One potential explanation is that many motifs are not accessible for binding due to the action of chromatin and DNA methylation. We are using mammalian stem cell models to understand this important interplay between gene regulation, chromatin structure and DNA methylation. We study the dynamics of the epigenome and test regulatory models in cellular models by genetic perturbation and genome editing approaches.
In my talk I will discuss our recent efforts in understanding how the sensitivity to DNA methylation can limit transcription factor binding in the context of the cell and how TFs rely on specific chromatin remodelers for access to their binding sites.
Bio:
Education:
1998 PhD, Technical University, Braunschweig (D)
1995 MSc, Technical University, Braunschweig (D)
Positions held:
2019- Co-Director FMI
2008- Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel (CH)
2003-2007 Junior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel (CH)
1998-2003 Postdoctoral Fellow, Fred Hutchinson Cancer Research Center, Seattle, WA (USA)
Abstract:
Transcription factors only bind a minority of their motifs in large mammalian genomes. One potential explanation is that many motifs are not accessible for binding due to the action of chromatin and DNA methylation. We are using mammalian stem cell models to understand this important interplay between gene regulation, chromatin structure and DNA methylation. We study the dynamics of the epigenome and test regulatory models in cellular models by genetic perturbation and genome editing approaches.
In my talk I will discuss our recent efforts in understanding how the sensitivity to DNA methylation can limit transcription factor binding in the context of the cell and how TFs rely on specific chromatin remodelers for access to their binding sites.
Bio:
Education:
1998 PhD, Technical University, Braunschweig (D)
1995 MSc, Technical University, Braunschweig (D)
Positions held:
2019- Co-Director FMI
2008- Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel (CH)
2003-2007 Junior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel (CH)
1998-2003 Postdoctoral Fellow, Fred Hutchinson Cancer Research Center, Seattle, WA (USA)
Practical information
- Informed public
- Free