Turning Capsule Catalysis Inside Out: Novel Approaches Utilizing Innately-Polarized Pd2L4 Scaffolds

Substrate pre-organization remains the paradigm for bio-inspired catalytic strategies using supramolecular capsule systems. The scarcity of capsule-catalyzed annulation reactions (A+B→C) highlights the limitation of this approach—while co-encapsulation can give significant acceleration, product inhibition frequently halts turnover. In this talk, two novel and distinct methods for realizing capsule-catalyzed annulation processes will be described, both involving the host-guest chemistry of simple Pd2L4 assemblies.