[ U.S. CDMRP - ALS Therapeutic Development Award | Research Funding ]

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Date and time 27.03.2020  
Category Call for proposal
Aim: Through the Congressionally Directed Medical Research Program (CDMRP), the Department of Defense is announcing the Amyotrophic Lateral Sclerosis (ALS) Research Program Therapeutic Development Award. This Award supports research ranging from validation of therapeutic leads through U.S. Food and Drug Administration (FDA) Investigational New Drug (IND)-enabling studies. The proposed studies are expected to be empirical in nature and product-driven. Preliminary data are required, including efficacy in at least one ALS-relevant model system with a lead molecule/class of compounds. The availability of validated biomarkers or biomarker development/characterization, in parallel to the main therapeutic effort and for use in eventual clinical trials, is a critical component of the FY20 ALSRP Therapeutic Development Award. Applicants with limited ALS experience are strongly encouraged to include collaborators with substantial expertise in the relevant ALS model systems, endpoints, and pathophysiology.

Biomarker development and/or characterization (if not already validated), in parallel to the main therapeutic effort, is a critical component of the FY20 ALSRP Therapeutic Development Award. Efforts may include development/characterization of target engagement biomarkers, pharmacodynamic biomarkers to measure the biological effect of an investigational therapeutic, and/or predictive/cohort-selective biomarkers that indicate whether a specific therapy will be effective in an individual patient or patient subgroup.

Funding:        max. $1’000’000

Duration:       3 years

Eligibility: Applicants from international organizations or institutions are eligible to apply, and there are no citizenship restrictions. Applicants must be independent investigators, but can come from any academic level.

How to Apply: Pre-applications are submitted through the eBRAP platform. They should contain contact information, a list of collaborators and key personnel, a preproposal narrative, and supporting documentation as suggested on the platform. Full applications (by invitation) will be made via a Grants.gov workspace. Full application packages can be downloaded from Grants.gov at any time.

Pre-Application Deadline: 27 March 2020, 5:00 p.m.
Full Application Deadline: 23 July 2020, 11:59 p.m. EST

Grants.gov Funding Opportunity Number: W81XWH-20-ALSRP-TDA

Further information
  • To see the program announcement, navigate to the search page on Grants.gov and search for the Opportunity Number W81XWH-20-ALSRP-TDA
  • For questions about the eBRAP or Grants.gov platforms, contact the Research Office.

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  • Free

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