[ U.S. DEPARTMENT OF DEFENSE - Reconstructive Transplant Research Program Investigator-Initiated Research Award | Research funding ]
Event details
| Date | 17.07.2019 |
| Category | Call for proposal |
Aim: Through the Congressionally Directed Medical Research Program (CDMRP), the Department of Defense is announcing the Reconstructive Transplant Research Program (RTRP) for 2019. The Investigator-Initiated Research Award is intended to support studies that have the potential to make an important contribution to reconstructive transplant research, patient care, and/or quality of life. Though the RTRP Investigator-Initiated Research Award mechanism supports groundbreaking research, all projects must demonstrate solid scientific rationale with military-relevant utility. Multi-institutional collaborations among clinicians and research scientists are encouraged.
To meet the intent of the FY19 RTRP Investigator-Initiated Research Award mechanism, applicants must address at least one of the FY19 RTRP Focus Areas listed at the end of this announcement. Applications may focus on any phase of research from basic through translational, including preclinical studies in animal models, human subjects, human anatomical substances, as well as correlative studies associated with an existing clinical trial.
Multiple Principal Investigator (PI) Option: The Investigator-Initiated Research Award mechanism includes an option for up to four PIs. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The other PI(s) will be identified as a Partnering PI(s).
Funding: Maximum USD $ 1’000’000 (Single PI)
Maximum USD $ 1’500’000 (Multiple PIs)
Duration: 3 years
Eligibility: Applicants from international organizations or institutions are eligible to apply, and there are no citizenship restrictions. Independent investigators at all academic levels (or equivalent) are eligible to submit applications.
How to Apply: Pre-applications are submitted through the eBRAP platform. They should contain contact information, a list of collaborators and key personnel, a preproposal narrative, and supporting documents as suggested on the platform. For the Multiple PI option, the Initiating PI must complete the pre-application submission process and submit the contact information for each Partnering PI. Full applications (by invitation) will be made via a Grants.gov workspace. Full application packages can be downloaded from Grants.gov at any time.
Pre-Application Deadline: 17 July 2019, 5:00 p.m. EST (23:00 CET)
Full Application Deadline: 16 October 2019, 11:59 p.m. EST (05:59 12 Sep, CET)
Grants.gov Funding Opportunity Number: W81XWH-19-RTRP-IIRA
Further information
FY19 RTRP Focus Areas
To meet the intent of the FY19 RTRP Investigator-Initiated Research Award mechanism, applicants must address at least one of the FY19 RTRP Focus Areas listed at the end of this announcement. Applications may focus on any phase of research from basic through translational, including preclinical studies in animal models, human subjects, human anatomical substances, as well as correlative studies associated with an existing clinical trial.
Multiple Principal Investigator (PI) Option: The Investigator-Initiated Research Award mechanism includes an option for up to four PIs. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The other PI(s) will be identified as a Partnering PI(s).
Funding: Maximum USD $ 1’000’000 (Single PI)
Maximum USD $ 1’500’000 (Multiple PIs)
Duration: 3 years
Eligibility: Applicants from international organizations or institutions are eligible to apply, and there are no citizenship restrictions. Independent investigators at all academic levels (or equivalent) are eligible to submit applications.
How to Apply: Pre-applications are submitted through the eBRAP platform. They should contain contact information, a list of collaborators and key personnel, a preproposal narrative, and supporting documents as suggested on the platform. For the Multiple PI option, the Initiating PI must complete the pre-application submission process and submit the contact information for each Partnering PI. Full applications (by invitation) will be made via a Grants.gov workspace. Full application packages can be downloaded from Grants.gov at any time.
Pre-Application Deadline: 17 July 2019, 5:00 p.m. EST (23:00 CET)
Full Application Deadline: 16 October 2019, 11:59 p.m. EST (05:59 12 Sep, CET)
Grants.gov Funding Opportunity Number: W81XWH-19-RTRP-IIRA
Further information
- To see the program announcement, navigate to the search page on Grants.gov and search for the Opportunity Number W81XWH-19-RTRP-IIRA.
- For questions about the eBRAP or Grants.gov platforms, contact the Research Office.
FY19 RTRP Focus Areas
- Reduce the risks of VCA-associated immunosuppression
- Define the unique mechanisms of VCA immunogenicity
- Develop novel approaches for improving VCA immune tolerance
- Identify unique immunosuppression requirements for VCA compared to other solid organ transplants
- Develop reliable non-invasive methods or tools for monitoring VCA graft rejection
- Develop reliable non-invasive biomarkers for monitoring chronic VCA graft rejection in a large animal model
- Identify and/or validate new peripheral biomarkers for acute and chronic rejection
- Develop assays or devices for clinical graft monitoring utilizing validated biomarkers
- Advance existing or develop innovative ex vivo tissue preservation strategies to extend the timeline between procurement and transplantation
- Develop novel approaches and models for perfused, hypothermic, high subzero and low subzero, or static preservation strategies
- Determine the extent to which VCA tissue preservation technology impacts VCA immunogenicity
Practical information
- General public
- Free