Visualizing the benign-to-malignant transition

Scott W. Lowe earned his bachelor’s degree from the University of Wisconsin-Madison and a Ph.D. from the Massachusetts Institute of Technology. Dr. Lowe began his independent research at Cold Spring Harbor Laboratory, where his group made significant contributions to understanding the p53 tumor suppressor, multi-step carcinogenesis, cellular senescence, and tumor-cell drug resistance. At MSKCC, his team integrates mouse models, genetics, and genomics to explore the interactions between tumor cells and their environment. This work has led to new discoveries relating to the genetic and epigenetic drivers of cancer evolution and how cellular senescence can influence immune surveillance and be targeted therapeutically.  During his career, Dr. Lowe has mentored over 100 trainees, many of whom have gone on to independent faculty positions.  He has received numerous awards, including the Sidney Kimmel Scholar Award, Rita Allen Scholar Award, the American Association for Cancer Research (AACR) Outstanding Investigator Award and G.H.A. Clowes Award, the Paul Marks Prize, and the Alfred G. Knudsen Award from the NIH. He is a member of the American Academy of Arts and Sciences, the National Academy of Sciences, and the National Academy of Medicine, and is a Fellow of the AACR.