Regulation of adipose tissue plasticity
Event details
| Date | 13.03.2017 |
| Hour | 13:30 › 14:30 |
| Speaker | Christian WOLFRUM ETH Zürich, Switzerland |
| Location | |
| Category | Conferences - Seminars |
SEMINAR SERIES: Trends in Physiology and Metabolism (Bio-682)
Abstract:
Brown adipose tissue has received a substantial amount of interest after the discovery of its presence in adult humans as a possible target tissue to increase systemic energy expenditure and thereby improve metabolic control or even affect weight loss. Brown adipocytes are, based on current knowledge, divided into two classes, namely the classical brown adipocytes mainly found in rodents in the intrascapular region (iBAT). A second type of brown adipocytes named either beige or brite (brown in white) adipocytes has been described in the inguinal white adipose tissue depot (ingWAT). As targeted therapies to induce brown adipose tissue mass and function rely on the knowledge of the precise origin of either cell type, multiple studies have investigated the formation of brown and brite adipocytes using in vitro as well as in vivo model systems. The two main pathways leading to increased brown adipose tissue formation are thought to be on the one hand de novo formation from precursor cells and on the other hand interconversion from white adipocytes. The lecture will focus on origin of white, brite and brown adipocytes and discuss the current knowledge regarding the function differences between these types of adipocytes, as well as their formation in varying physiological conditions.
Abstract:
Brown adipose tissue has received a substantial amount of interest after the discovery of its presence in adult humans as a possible target tissue to increase systemic energy expenditure and thereby improve metabolic control or even affect weight loss. Brown adipocytes are, based on current knowledge, divided into two classes, namely the classical brown adipocytes mainly found in rodents in the intrascapular region (iBAT). A second type of brown adipocytes named either beige or brite (brown in white) adipocytes has been described in the inguinal white adipose tissue depot (ingWAT). As targeted therapies to induce brown adipose tissue mass and function rely on the knowledge of the precise origin of either cell type, multiple studies have investigated the formation of brown and brite adipocytes using in vitro as well as in vivo model systems. The two main pathways leading to increased brown adipose tissue formation are thought to be on the one hand de novo formation from precursor cells and on the other hand interconversion from white adipocytes. The lecture will focus on origin of white, brite and brown adipocytes and discuss the current knowledge regarding the function differences between these types of adipocytes, as well as their formation in varying physiological conditions.
Links
Practical information
- Informed public
- Free
Organizer
- Prof. Lluis Fajas (UNIL), Prof. Kei Sakamoto (NIHS) and Prof. Kristina Schoonjans (EPFL)
Contact
- Prof. Kei Sakamoto (NIHS) - [email protected]