The non-canonical Hedgehog/AMPK pathway regulates polyamine metabolism to support neuronal and medulloblastoma cell growth
Event details
| Date | 29.04.2014 |
| Hour | 10:30 › 11:30 |
| Speaker | Davide D’Amico, PhD, University of Rome La Sapienza (I) |
| Location | |
| Category | Conferences - Seminars |
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)
Abstract:
Inappropriate activation of the Hedgehog signaling is a leading cause of medulloblastoma and pharmacological targeting of Hedgehog downstream components represents a promising therapeutic strategy. This seminar will discuss how Hedgehog promotes polyamine biosynthesis by engaging a non-canonical axis leading to ODC translation. This process is governed by AMPK, which phosphorylates CNBP in response to Hedgehog activation. Notably, elevated CNBP, ODC and polyamines are hallmarks of Hedgehog-dependent medulloblastoma and inhibition of ODC with DFMO efficiently blocks Hedgehog-dependent proliferation of medulloblastoma cells. Together, these data illustrate an unexpected auxiliary mechanism of metabolic control by a morphogenic pathway with relevant implications in cancer therapy.
Bio:
D. D’Amico, currently at the Department of Molecular Medicine, University of Rome "La Sapienza", Rome (I), holds a Ph.D. degree from La Sapienza obtained under the supervision of Prof. Gianluca Canettieri (Research Unit on Epigenetics, Metabolism and Cancer).
Abstract:
Inappropriate activation of the Hedgehog signaling is a leading cause of medulloblastoma and pharmacological targeting of Hedgehog downstream components represents a promising therapeutic strategy. This seminar will discuss how Hedgehog promotes polyamine biosynthesis by engaging a non-canonical axis leading to ODC translation. This process is governed by AMPK, which phosphorylates CNBP in response to Hedgehog activation. Notably, elevated CNBP, ODC and polyamines are hallmarks of Hedgehog-dependent medulloblastoma and inhibition of ODC with DFMO efficiently blocks Hedgehog-dependent proliferation of medulloblastoma cells. Together, these data illustrate an unexpected auxiliary mechanism of metabolic control by a morphogenic pathway with relevant implications in cancer therapy.
Bio:
D. D’Amico, currently at the Department of Molecular Medicine, University of Rome "La Sapienza", Rome (I), holds a Ph.D. degree from La Sapienza obtained under the supervision of Prof. Gianluca Canettieri (Research Unit on Epigenetics, Metabolism and Cancer).
Practical information
- Informed public
- Free
Organizer
- Kristina Schoonjans and Johan Auwerx (for the LIMNA Alliance)
Contact
- Johan Auwerx
------------------
(*) IMPORTANT NOTICE : All external participants have to pass through SV Reception/Welcome Desk to be able to access to AI 1153. Contact person to call upon arrival at SV Reception Desk: Johan Auwerx 30951 / Administrative Assistant: 39522.