Advanced Genetic Systems to Improve Molecular Diagnostics and Targeted Therapies
Event details
| Date | 08.09.2015 |
| Hour | 13:00 |
| Speaker | Prof. Dr. med. Dieter Saur, II. Medizinische Klinik und Poliklinik Klinikum rechts der Isar der TU München, Germany |
| Location | |
| Category | Conferences - Seminars |
Maintenance and drug resistance of gastrointestinal cancer subtypes depends on cancer cell intrinsic mechanisms and a stroma that supports tumor growth. Mouse models have provided important insights into the evolution of these cancer types, but there are no models that allow secondary genetic manipulation of autochthonous tumors, the tumor microenvironment or the metastatic host niche once the tumor has formed. We have generated inducible dual-recombinase based cancer models that permit spatial and temporal control of gene expression. This tool provides unparalleled access to the native biology of cancer cells and their hosting stroma, and rigorous genetic validation of candidate therapeutic targets. We performed tumor cell-autonomous and non-autonomous targeting, uncovered hallmarks of human multistep carcinogenesis, validated genetic tumor therapy, and showed that mast cells in the tumor microenvironment, which had been thought to be key oncogenic players, are in fact dispensable for tumor formation in the pancreas.
Practical information
- Informed public
- Free
Organizer
- Freddy Radtke
Contact
- Freddy Radtke