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An evolutionary switch in J-protein biology affects prokaryotic and eukaryotic protein disaggregation

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Date and time 15.11.2016 14:1516:00  
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Speaker Nadinath Nillegoda, Heidelberg University, Germany
Category Conferences - Seminars
BIOLOGICAL & STATISTICAL PHYSICS SEMINAR

Abstract:
Decreased cellular capacity in protein aggregate clearance manifests in cellular deterioration, aging and disease. Toxic intracellular aggregates formed by misfolded proteins are reversed and/or limited by multi-tiered cellular quality control systems.

We recently reported J-proteins of classes A and B cooperate via interclass complex formation to mediate substrate specificity of Hsp70-based aggregate solubilizing systems (disaggregases) in metazoa. What remains unclear is whether these mixed class J-protein complexes occur also in non-metazoans given the fact that orthologs of both classes exist in bacteria, fungi, plant and protozoa. Using a broad set of experimental approaches, we find a switching in J-protein biology at the prokaryote-to-eukaryote transition where class members network allowing for the emergence of powerful, yet regulatable eukaryotic disaggregase systems.

We also describe a naturally occurring strategy to correctly pair J-proteins of different types, ensuing functional integrity within networks in expanded J-protein families during rise of complex life.

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