BioE COLLOQUIA SERIES: Reconstructing Development and Regeneration Using Single-Cell Genomics


Event details

Date and time 11.11.2019 12:15  
Place and room
Speaker Prof. Barbara Treutlein, ETH Zürich, Department of Biosystems Science and Engineering, Basel (CH)
Category Conferences - Seminars
(sandwiches served)

In biology, there are many scenarios where cells transit from one cell state or identity to another. During development, stem cells make fate decisions and differentiate into various mature cell types within a complex organ. During regeneration, differentiated cells can acquire a stem cell state and re-differentiate along multiple lineages. Single-cell genomics methods have proven to be powerful tools to illuminate the intermediate states that occur during these cellular transitions. I will discuss our work using single-cell transcriptomics to reconstruct molecular paths during organ development and regeneration. First, I will present our work using single-cell transcriptomics to reconstruct human organoid development and to compare these systems with their primary counterparts. We are now manipulating these systems to study gene function during human development and disease. Second, I will discuss our work exploring regeneration of the axolotl forelimb, where we found that connective tissue cell types in the uninjured adult limb revert to multipotent progenitor states that re-pattern and execute genetic programs observed in the embryonic limb.

Barbara Treutlein is Associate Professor of Quantitative Developmental Biology at Department of Biosystems Science and Engineering (D-BSSE), the Basel branch of ETH Zürich. Her research focuses on human developmental biology, with a focus on how complex organs such as the liver and brain form. Barbara was a Tenure Track Assistant Professor at the Technical University of Munich and Research Group Leader at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany.

Zoom link for attending remotely:

Practical information

  • Informed public
  • Free