Biomolecular design in four dimensions
Event details
| Date | 17.04.2024 |
| Hour | 14:00 › 15:00 |
| Speaker | Prof. Florian Praetorius, Institute of Science and Technology Austria |
| Location | Online |
| Category | Conferences - Seminars |
| Event Language | English |
BIOENGINEERING SEMINAR
Abstract:
Wouldn’t it be great if we could control the spatial arrangement of molecules on the nanometer- to micrometer scale, building molecular assemblies with arbitrary shapes in which the chemical properties can be tailored with molecular resolution? And wouldn’t it be even greater if we could reconfigure these assemblies in response to external stimuli? The Praetorius lab for biomolecular design at ISTA works towards these goals using de novo protein design with a few sprinkles of DNA nanotechnology. We use computational tools to design new proteins from scratch, with functions and properties that can not be found in natural proteins. One of our main interests is to use DNA to introduce addressability into otherwise symmetric protein assemblies. Besides that, we are interested in designing stimulus-responsive proteins and assemblies such as switchable binders or assemblies that can be triggered to assemble or disassemble. In this presentation I will give an overview of our research interests and explain some of the strategies we employ. Since our lab just started, I will also include some results from my time in the Baker lab and try to mention some key learnings from our design projects.
Bio:
Florian Praetorius is Associate Professor at the Institute of Science and Technology Austria.
Zoom link for attending remotely: https://epfl.zoom.us/j/62383401524
Abstract:
Wouldn’t it be great if we could control the spatial arrangement of molecules on the nanometer- to micrometer scale, building molecular assemblies with arbitrary shapes in which the chemical properties can be tailored with molecular resolution? And wouldn’t it be even greater if we could reconfigure these assemblies in response to external stimuli? The Praetorius lab for biomolecular design at ISTA works towards these goals using de novo protein design with a few sprinkles of DNA nanotechnology. We use computational tools to design new proteins from scratch, with functions and properties that can not be found in natural proteins. One of our main interests is to use DNA to introduce addressability into otherwise symmetric protein assemblies. Besides that, we are interested in designing stimulus-responsive proteins and assemblies such as switchable binders or assemblies that can be triggered to assemble or disassemble. In this presentation I will give an overview of our research interests and explain some of the strategies we employ. Since our lab just started, I will also include some results from my time in the Baker lab and try to mention some key learnings from our design projects.
Bio:
Florian Praetorius is Associate Professor at the Institute of Science and Technology Austria.
Zoom link for attending remotely: https://epfl.zoom.us/j/62383401524
Practical information
- Informed public
- Free
Organizer
- Prof. Bruno Correia, Laboratory of Protein Design and Immunoengineering (LPDI), Institute of Bioengineering (IBI), École polytechnique fédérale de Lausanne (EPFL)
Contact
- Ms. Suzanne Balharry, Laboratory of Protein Design and Immunoengineering (LPDI), Institute of Bioengineering (IBI), École polytechnique fédérale de Lausanne (EPFL)