Breaking the rules with natural and non-natural cyclic peptides

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Event details

Date and time 17.11.2020 16:1517:15  
Place and room
Zoom
Online https://epfl.zoom.us/j/87665377407
Speaker Prof. Scott Lokey, UC Santa Cruz
Category Conferences - Seminars

The laboratory of Prof. Scott Lokey is studying the membrane permeability in molecules whose structures violate classical predictors of “drug-likeness” (e.g. Lipinski's "rule of five") based on molecular weight and polarity. Many of these ”rule breakers” are natural products such as the cyclic peptide cyclosporine A, a highly effective immunosuppressive drug that is orally bioavailable despite its molecular weight of ~1200. The Lokey lab is investigating the physico-chemical properties of molecules like cyclosporine and, using synthetic model systems, are uncovering interesting relationships between structure, conformation, and membrane permeability in these molecules.
 

Practical information

  • Informed public
  • Free

Contact

  • C. Heinis

Tags

cbseminar

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