Cancer Genomes in 3D
|Date and time||25.09.2019 – 12:15 › 13:15|
|Place and room|
|Speaker||Robert Babak Faryabi, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA|
|Category||Conferences - Seminars|
Abstract: The importance of epigenetic changes in cancer pathogenesis has become increasingly clear, yet the underlying mechanisms remain obscure. Our research focuses on identifying epigenetic changes that can render cancer cells addicted to specific transcriptional regulators. I will present evidence that oncogenic subversion of transcription factors leads to disruption of chromosome topology and instruct enhancer elements to aberrantly contact and activate intact proto-oncogenes. These aberrant states can drive cancer cell growth and proliferation in the absence of genetic mutations, and may also confer drug resistance. I will also discuss our efforts to develop single-cell molecular tools and experimental models for characterizing epigenetic mechanisms of oncogenesis and attendant therapeutic opportunities.