CellStudio Platform: Advancing Spatially-Resolved Analysis of Cell Secretion

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Event details

Date 15.05.2025
Hour 10:1511:30
Speaker Prof. Lourdes Basabe-Desmonts, Microfluidics Cluster, Research Centre Lucio Lascaray, University of the Basque Country UPV/EHU, Vitoria-Gasteiz (ESP)
Location Online
Category Conferences - Seminars
Event Language English
BIOENGINEERING SEMINAR
 
Abstract:
In this talk I will present advances in spatially-resolved cell analysis using CellStudio, a modular and accessible platform for monitoring cellular secretions. Combining printing and vacuum lithography, and bead-based biosensing, CellStudio enables high-sensitivity detection of secreted proteins within structured cell cultures using standard lab equipment. We demonstrate its versatility through four studies: detection of VEGF and FGF-2 in stem and cancer cells; integration of a structure-switching aptamer for real-time VEGF sensing; solid-phase presentation of growth factors via functionalized beads to control stimulation; and monitoring of IFN-γ secretion from Jurkat T cells under CD3/CD4 co-stimulation. Together, these works highlight CellStudio's potential as a robust, user-friendly tool for investigating cell behaviour in controlled microenvironments.

Bio:
Lourdes Basabe studied chemistry at the Universidad Autónoma de Madrid until 2002. Then, she moved to the University of Twente in The Netherlands, where she completed her PhD in 2006 under the supervision of Dr. Crego Calama and Prof. David Reinhoudt at the Supramolecular Chemistry Group within the MESA+ Institute for Nanotechnology. In 2006 she joined the Biomedical Diagnostics Institute in Dublin, Ireland, where in 2009 she became Team Leader in Microfluidics for Platelet Biology. In 2012, she was awarded an Ikerbasque Research Professorship and she moved to CICmicroGUNE in the Basque Country, Spain. In 2014, Lourdes joined the BIOMICS research group at the University of the Basque Country, led by Prof. Martinez de Pancorbo, where she established her own independent research team: BIOMICS-microfluidics, focused on the development of lab-on-a-chip technologies. In June 2015 she co-founded the Microfluidics Cluster UPV/EHU with Dr. Fernando Benito-Lopez´s group. And in 2019 she promoted the creation of the Microfluidics and Biomics (M&B) Cluster UPV/EHU, Lourdes Basabe is the director of the M&B Cluster UPV/EHU which is finacially supported by the Basque Government.
Lourdes has a multidisciplinary scientific background marked by a high international mobility. In 2010 Lourdes she was awarded with the UK and Ireland L'Oreal UNESCO for Women in Science Fellowship. The research of Lourdes Basabe-Desmonts is published in peer reviewed publications at high impact international journals (ACS Nano, JACS, Advanced Materials, Angewandte Chemie International Edition, Lab on a Chip, Langmuir, Chemical Society Reviews, etc). She is also inventor of several patents.
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Zoom link for attending remotely: https://epfl.zoom.us/j/69559099320


Instructions for 1st-year Ph.D. students planning to attend this talk, who are under EDBB’s mandatory seminar attendance rule:
IN CASE you cannot attend in-person in the room, please make sure to
  1. send D. Reinhard a note well ahead of time (ideally before seminar day), informing that you plan to attend the talk online, and, during seminar:
  2. be signed in on Zoom with a recognizable user name (not any alias making it difficult or impossible to identify you).
Students attending the seminar in-person should collect a confirmation signature after the talk - please print your own signature sheet beforehand (69 kB pdf available for download here). IMPORTANTLY: hang on to this sheet as no signature record is being kept by anyone else!

Practical information

  • Informed public
  • Free

Organizer

Contact

  • Marie Rodriguez

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