CellStudio Platform: Advancing Spatially-Resolved Analysis of Cell Secretion

Event details
Date | 15.05.2025 |
Hour | 10:15 › 11:30 |
Speaker | Prof. Lourdes Basabe-Desmonts, Microfluidics Cluster, Research Centre Lucio Lascaray, University of the Basque Country UPV/EHU, Vitoria-Gasteiz (ESP) |
Location | Online |
Category | Conferences - Seminars |
Event Language | English |
BIOENGINEERING SEMINAR
Abstract:
In this talk I will present advances in spatially-resolved cell analysis using CellStudio, a modular and accessible platform for monitoring cellular secretions. Combining printing and vacuum lithography, and bead-based biosensing, CellStudio enables high-sensitivity detection of secreted proteins within structured cell cultures using standard lab equipment. We demonstrate its versatility through four studies: detection of VEGF and FGF-2 in stem and cancer cells; integration of a structure-switching aptamer for real-time VEGF sensing; solid-phase presentation of growth factors via functionalized beads to control stimulation; and monitoring of IFN-γ secretion from Jurkat T cells under CD3/CD4 co-stimulation. Together, these works highlight CellStudio's potential as a robust, user-friendly tool for investigating cell behaviour in controlled microenvironments.
Bio:
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Zoom link for attending remotely: https://epfl.zoom.us/j/69559099320
Instructions for 1st-year Ph.D. students planning to attend this talk, who are under EDBB’s mandatory seminar attendance rule:
IN CASE you cannot attend in-person in the room, please make sure to
Abstract:
In this talk I will present advances in spatially-resolved cell analysis using CellStudio, a modular and accessible platform for monitoring cellular secretions. Combining printing and vacuum lithography, and bead-based biosensing, CellStudio enables high-sensitivity detection of secreted proteins within structured cell cultures using standard lab equipment. We demonstrate its versatility through four studies: detection of VEGF and FGF-2 in stem and cancer cells; integration of a structure-switching aptamer for real-time VEGF sensing; solid-phase presentation of growth factors via functionalized beads to control stimulation; and monitoring of IFN-γ secretion from Jurkat T cells under CD3/CD4 co-stimulation. Together, these works highlight CellStudio's potential as a robust, user-friendly tool for investigating cell behaviour in controlled microenvironments.
Bio:
Zoom link for attending remotely: https://epfl.zoom.us/j/69559099320
Instructions for 1st-year Ph.D. students planning to attend this talk, who are under EDBB’s mandatory seminar attendance rule:
IN CASE you cannot attend in-person in the room, please make sure to
- send D. Reinhard a note well ahead of time (ideally before seminar day), informing that you plan to attend the talk online, and, during seminar:
- be signed in on Zoom with a recognizable user name (not any alias making it difficult or impossible to identify you).
Practical information
- Informed public
- Free
Organizer
Contact
- Marie Rodriguez