Cellular and Pathogenic Protein Indicators of Disease in Huntington’s Disease and X-Linked Dystonia Parkinsonism Human Brain Tissue


Event details

Date 06.06.2023
Hour 10:0011:00
Speaker Malvindar Singh-Bains, Ph.D. and Adelie Tan, Ph.D., University of Auckland Centre for Brain Research, Auckland (NZ)
Location Online
Category Conferences - Seminars
Event Language English
Huntington’s disease (HD) and X-linked Dystonia Parkinsonism (XDP) are both hereditary, progressive neurogenerative brain conditions featuring heterogenous movement, psychiatric and cognitive disturbances with variable symptomatology between patients. Dr. Singh-Bains’s PhD and early post-doctoral research focused on elucidating the cellular basis of symptom heterogeneity in HD through conducting design-based stereological studies in clinically characterized post-mortem human brain tissue housed within the Neurological Foundation Human Brain Bank in the Centre for Brain Research, University of Auckland. Her expertise in human brain tissue processing and dissection resulted in her involvement in the development of the first human brain bank in the Philippines as part of an international collaborative effort to characterize XDP, a newly discovered condition endemic to the Filipino Island of Panay. Dr. Tan recently completed her PhD under the supervision of Dr. Singh-Bains focusing on the characterization of neurovascular cellular involvement in HD cortical tissue through the development of high-throughout automated analysis approaches applied to human brain tissue microarrays, combined with in vitro characterization of living primary human brain cells (pericytes) derived from HD post-mortem tissue. This presentation will focus on current projects (1) elucidating the involvement of pathogenic proteins in HD and (2) elucidating the neuropathology of XDP, through a combination of high-throughout and detailed analysis approaches in post-mortem human brain tissue.

Zoom link for attending remotely: https://epfl.zoom.us/j/67113149944