Dearomatization of indoles for the total synthesis of natural products
Event details
| Date | 23.11.2021 |
| Hour | 16:15 › 17:15 |
| Speaker | Dr. Guillaume Vincent, Université Paris-Sud, France https://www.icmmo.u-psud.fr/fr/perso/guillaume-vincent/ |
| Location |
AUDITOIRE CE1
|
| Category | Conferences - Seminars |
| Event Language | English |
Dearomatization of Indoles for the Total Synthesis of Natural Products
Guillaume Vincent
Institut de Chimie Moléculaire et des Matériaux d’Orsay
Université Paris Saclay, CNRS
91405 Orsay, France
Email: [email protected]
We aim to study the chemistry of the indole nucleus and to develop original strategies towards dearomatisation reactions of indoles in order to obtain biologically relevant three dimensional scaffolds (“drug like”) and to achieve the total synthesis of indoline-containing natural products.1,2 To this end, we developed synthetic methods via the Umpolung of N-Ac indoles and oxidative couplings of indoles.3,4
Guillaume Vincent
Institut de Chimie Moléculaire et des Matériaux d’Orsay
Université Paris Saclay, CNRS
91405 Orsay, France
Email: [email protected]
We aim to study the chemistry of the indole nucleus and to develop original strategies towards dearomatisation reactions of indoles in order to obtain biologically relevant three dimensional scaffolds (“drug like”) and to achieve the total synthesis of indoline-containing natural products.1,2 To this end, we developed synthetic methods via the Umpolung of N-Ac indoles and oxidative couplings of indoles.3,4
- Lachkar, D. ; Denizot, N.; Poupon, E.; Evanno, L.; Vincent, G. et al. Nat. Chem. 2017, 9, 793-798.
- a) Jarret, M.; Tap, A.; Kouklovsky, C.; Poupon, E.; Evanno, L.; Vincent, G. Angew. Chem. Int. Ed. 2018, 57, 12294-12298; b) Jarret, M.; Turpin, V.; Tap, A.; Gallard, J.-F.; Kouklovsky, C.; Poupon, E.; Vincent, G.; Evanno, L. Angew. Chem. Int. Ed. 2019, 58, 9861-9865; c) Dou, Y.; Kouklovsky, C.; Gandon, V.; Vincent, G. Angew. Chem. Int. Ed. 2020, 59, 1527.
- a) Denizot, N.; Poulilhès, A.; Cucca, M.; Beaud, R.; Guillot, R.; Kouklovsky, C.; Vincent, G. Org. Lett. 2014, 16, 5752-5755; b) Tomakinian, T.; Guillot, R.; Kouklovsky, C. Vincent, G. Ang. Chem. Int. Ed. 2014, 53, 11881-11885; c) Beaud, R.; Guillot, R.; Kouklovsky, C. Vincent, G. Ang. Chem. Int. Ed. 2012, 51, 12546-12550.
- Wu, J.; Dou, Y.; Guillot, R.; Vincent, G. J. Am. Chem. Soc. 2019, 141, 2832-2837.
Practical information
- General public
- Free
Organizer
- Prof. Jieping Zhu [email protected] https://www.epfl.ch/labs/lspn/
Contact
- Prof. Jieping Zhu [email protected] https://www.epfl.ch/labs/lspn/