Defining the landscape of Host-Microbiota-Diet interaction in intestinal inflammation & cancer
Event details
| Date | 11.03.2014 |
| Hour | 14:00 › 15:00 |
| Speaker | Yiorgos Apidianakis |
| Location | |
| Category | Conferences - Seminars |
The gastrointestinal tract is habitable by a variety of microorganisms and it is often a tissue inflicted by inflammation. Much discussion is raised in recent years about the role of microbiota in intestinal inflammation and its role in intestinal cancer. I will discuss our work on Drosophila melanogaster models of tumorigenesis and tumor cell invasion upon intestinal infection. In Drosophila midgut, bacteria that cause enterocyte damage induce intestinal stem cell proliferation, which is diverted towards aberrant stem cell expansion upon oncogene expression to induce dysplastic tumors. In Drosophila hindgut, oncogenes synergize with the innate immune response to induce tumor cell invasion and dissemination to distant sites. Based on these Drosophila models a multi-parameter and combinatorial analysis of host genetic factors, human intestinal microbiota and diet can be performed to systematically assess pivotal aspects of intestinal inflammation and cancer.
Practical information
- General public
- Free
Organizer
- Prof. Bruno Lemaitre
Contact
- Prof. Bruno Lemaitre