Differentiation and functions of monocyte/macrophages
Event details
| Date | 18.11.2010 |
| Hour | 12:15 |
| Speaker | Frederic Geissman, INSERM, Necker-Enfants Malades research Institute |
| Location |
SV 1717A
|
| Category | Conferences - Seminars |
Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, whereas dendritic cells initiate and regulate adaptive immune responses, and are central to the development of immunologic memory and tolerance. Recent in vivo experimental approaches in the mouse have unveiled new aspects of the developmental and lineage relationships among these cell populations. Monocytes, macrophages and dendritic cells subsets share a common bone marrow progenitor, the MDP (Macrophage and DC progenitor), which express receptors for SCF, M-CSF and FLT3-L, and the chemokine receptor CX3CR1. However, distinct subsets of dendritic cells and macrophages are generated via separate differentiation pathways, which are beginning to be elucidated. Blood monocytes themselves consist in several functional subsets. A classical Gr1+ population of 'inflammatory' monocytes give rise to 'inflammatory' DCs while a second subset (Gr1-) have been shown to patrol blood vessels in the steady state, extravasate during infection or tissue damage, and give rise to 'M2'-type macrophages that may be involved in tissue repair. Despite this, the origin, differentiation cues, and precise functions for many tissue macrophages, monocytes, and dendritic cell subsets in mice remain to be elucidated. Another challenge that will be discussed is to identify corresponding cell populations in humans.
Practical information
- General public
- Free
Organizer
- Bruno Lemaitre
Contact
- Bruno Lemaitre